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Auditory environmental enrichment prevents anxiety-like behavior, but not cortisol responses, evoked by 24-h social isolation in zebrafish

2021; Elsevier BV; Volume: 404; Linguagem: Inglês

10.1016/j.bbr.2021.113169

1872-7549

Letícia Marchetto, Leonardo José Gil Barcellos, Gessi Koakoski, Suelen Mendonça Soares, Aline Pompermaier, Victória Costa Maffi, Roberta Angnes da Costa, Carolina G. da Silva, Natalie Renata Zorzi, Konstantin A. Demin, Allan V. Kalueff, Heloísa Helena de Alcântara Barcellos,

Animal Behavior and Reproduction

The zebrafish (Danio rerio) is widely used as a promising translational model organism for studying various brain disorders. Zebrafish are also commonly used in behavioral and drug screening assays utilizing individually tested (socially isolated) fish. Various sounds represent important exogenous factors that may affect fish behavior. Mounting evidence shows that musical/auditory environmental enrichment can improve welfare of laboratory animals, including fishes. Here, we show that auditory environmental enrichment mitigates anxiogenic-like effects caused by acute 24-h social isolation in adult zebrafish. Thus, auditory environmental enrichment may offer an inexpensive, feasible and simple tool to improve welfare of zebrafish stocks in laboratory facilities, reduce unwanted procedural stress, lower non-specific behavioral variance and, hence, collectively improve zebrafish data reliability and reproducibility.