Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes
2021; Royal Society of Chemistry; Volume: 12; Issue: 11 Linguagem: Inglês
10.1039/d0sc06605b
ISSN2041-6539
AutoresAmélie I. S. Sobczak, Kondwani Katundu, Fladia Phoenix, Siavash Khazaipoul, Ruitao Yu, Fanuel Lampiao, Fiona Stefanowicz, Claudia A. Blindauer, Samantha J. Pitt, Terry Smith, Ramzi Ajjan, Alan J. Stewart,
Tópico(s)Hemoglobinopathies and Related Disorders
ResumoZn 2+ is an essential regulator of coagulation. In plasma, Zn 2+ availability is fine-tuned by human serum albumin (HSA). Here we show that elevated fatty acid levels contribute to altered coagulation in type-2 diabetes through Zn 2+ mishandling by HSA.
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