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Repeated idiopathic anaphylaxis caused by povidone

2021; Elsevier BV; Volume: 126; Issue: 5 Linguagem: Inglês

10.1016/j.anai.2021.01.030

1534-4436

Maria A. Bruusgaard‐Mouritsen, Charlotte G. Mørtz, Lone Winther, Lene H. Garvey,

Contact Dermatitis and Allergies

Povidone, also known as polyvinylpyrrolidone (PVP) and E1201, is a synthetic, hydrophilic polymer used as an excipient in cosmetics, pharmaceutical products, and food. 1 Bergendorff O. Hansson C. Urticaria and anaphylaxis to povidone in a paracetamol preparation. J Eur Acad Dermatol Venereol. 2007; 21: 573-574 PubMed Google Scholar It is used as a lubricant and antiseptic in eye drops and contact lenses and is found in the disinfectant povidone iodine (Betadine, Alcon Nordic, Copenhagen, Denmark). 2 Liccioli G. Mori F. Barni S. Pucci N. Novembre E. Anaphylaxis to polyvinylpyrrolidone in eye drops administered to an adolescent. J Investig Allergol Clin Immunol. 2018; 28: 263-265 Crossref PubMed Scopus (4) Google Scholar , 3 Rönnau A.C. Wulferink M. Gleichmann E. et al. Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation. Br J Dermatol. 2000; 143: 1055-1058 Crossref PubMed Scopus (36) Google Scholar , 4 Bigliardi P.L. Alsagoff S.A.L. El-Kafrawi H.Y. Pyon J.K. Wa C.T.C. Villa M.A. Povidone iodine in wound healing: a review of current concepts and practices. Int J Surg. 2017; 44: 260-268 Crossref PubMed Scopus (111) Google Scholar Allergy to povidone is rare but has been reported with increasing frequency. We present a case of allergy to povidone diagnosed after repeated allergic reactions, over several years, to chemically unrelated drugs and idiopathic exposures.