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Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

2021; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 2 Linguagem: Inglês

10.3390/pathogens10020138

2076-0817

Yongjun Sui, Yonas Bekele, Jay A. Berzofsky,

COVID-19 Clinical Research Studies

Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.