A not-so-simple twist of fate
2021; Elsevier BV; Volume: 56; Issue: 4 Linguagem: Inglês
10.1016/j.devcel.2021.02.003
ISSN1878-1551
AutoresAlexandra F. Long, Tim Stearns,
Tópico(s)Congenital heart defects research
ResumoMulticiliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al., 2021Tasca A. Helmstädter M. Brislinger M.M. Haas M. Mitchell B. Walentek P. Notch signaling induces either apoptosis or cell fate change in multiciliated cells during mucociliary tissue remodeling.Dev. Cell. 2021; 56: 4Abstract Full Text Full Text PDF Scopus (6) Google Scholar show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.
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