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Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections

2021; BioMed Central; Volume: 21; Issue: 1 Linguagem: Inglês

10.1186/s12879-021-05878-2

1471-2334

David W. Eyre, Sheila Lumley, Denise O’Donnell, Nicole Stoesser, Philippa C. Matthews, Alison Howarth, Stephanie B. Hatch, Brian D. Marsden, Stuart Cox, Tim James, Richard J. Cornall, David I. Stuart, Gavin Screaton, Daniel Ebner, Derrick W. Crook, Christopher P. Conlon, Katie Jeffery, Timothy M. Walker, Tim Peto,

Advanced Biosensing Techniques and Applications

Thresholds for SARS-CoV-2 antibody assays have typically been determined using samples from symptomatic, often hospitalised, patients. In this setting the sensitivity and specificity of the best performing assays can both exceed 98%. However, antibody assay performance following mild infection is less clear.