Contribution of Atrial Fibrillation to In-Hospital Mortality in Patients With COVID-19
2021; Lippincott Williams & Wilkins; Volume: 14; Issue: 2 Linguagem: Inglês
10.1161/circep.120.009375
ISSN1941-3149
AutoresEnrico Guido Spinoni, Marco Mennuni, Andrea Rognoni, Leonardo Grisafi, Crizia Colombo, Veronica Lio, Giulia Renda, Melissa Foglietta, Ivan Petrilli, Damiano D’Ardes, Pier Paolo Sainaghi, Gianluca Aimaretti, Mattia Bellan, Luigi Mario Castello, Gian Carlo Avanzi, Françesco Della Corte, Marco Krengli, Mario Pirisi, Mario Malerba, Andrea Capponi, Sabina Gallina, Sante D. Pierdomenico, Francesco Cipollone, Giuseppe Patti, Emanuele Albano, Umberto Dianzani, Gianluca Gaïdano, Alessandra Gennari, Carla Gramaglia, Martina Solli, Ailia Giubertoni, Alessia Veia, Carlo Cisari, Paolo Amedeo Tillio, Paolo Aluffi Valletti, Francesco Barone‐Adesi, Michela Barini, Daniela Ferrante, Simona De Vecchi, Matteo Santagostino, Antonio Acquaviva, Elisa Calzaducca, Giuseppe Francesco Casciaro, Federico Ceruti, Micol Giulia Cittone, Davide Di Benedetto, Ileana Gagliardi, Greta Maria Giacomini, Irene Landi, Raffaella Landi, Giulia Francesca Manfredi, Anita Rebecca Pedrinelli, Cristina Rigamonti, Eleonora Rizzi, Carlo Smirne, Veronica Vassia, Roberto Arioli, Pietro Danna, Zeno Falaschi, Alessio Paschè, Ilaria Percivale, Domenico Zagaria, Michela Beltrame, Matteo Bertoli, Alessandra Galbiati, Clara Ada Gardino, Maria Luisa Gastaldello, Valentina Giai Via, Francesca Giolitti, Ilaria Inserra, Emanuela Labella, Ilaria Nerici, Laura Cristina Gironi, Edoardo Cammarata, Elia Esposto, Vanessa Tarantino, Elisa Zavattaro, Francesca Zottarelli, Tommaso Daffara, Alice Ferrero, Ilaria Leone, Alessandro Nuzzo, Giulia Baldon, Sofia Battistini, Emilio Chirico, Luca Lorenzini, María Martelli, Emanuela Barbero, Paolo Boffano, Matteo Brucoli, Massimiliano Garzaro, Alberto Pau, Stephanie Bertolin, Letizia Marzari, Gianluca Avino, Massimo Saraceno, Umberto Morosini, Alessio Baricich, Marco Invernizzi, Silvia Gallo, Claudia Montabone, Samuel Alberto Padelli, Lucio Boglione, Filippo Patrucco, Luigia Salamina, Francesca Baorda, Eleonora Croce, Irene Giacone,
Tópico(s)SARS-CoV-2 and COVID-19 Research
ResumoHomeCirculation: Arrhythmia and ElectrophysiologyVol. 14, No. 2Contribution of Atrial Fibrillation to In-Hospital Mortality in Patients With COVID-19 Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBContribution of Atrial Fibrillation to In-Hospital Mortality in Patients With COVID-19 Enrico Guido Spinoni, Marco Mennuni, Andrea Rognoni, Leonardo Grisafi, Crizia Colombo, Veronica Lio, Giulia Renda, Melissa Foglietta, Ivan Petrilli, Damiano D'Ardes, Pier Paolo Sainaghi, Gianluca Aimaretti, Mattia Bellan, Luigi Castello, Gian Carlo Avanzi, Francesco Della Corte, Marco Krengli, Mario Pirisi, Mario Malerba, Andrea Capponi, Sabina Gallina, Sante Donato Pierdomenico, Francesco Cipollone and Giuseppe Patti Enrico Guido SpinoniEnrico Guido Spinoni https://orcid.org/0000-0002-7980-1737 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Marco MennuniMarco Mennuni https://orcid.org/0000-0002-3795-8787 Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Andrea RognoniAndrea Rognoni https://orcid.org/0000-0002-6139-0263 Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Leonardo GrisafiLeonardo Grisafi https://orcid.org/0000-0001-5277-9907 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Crizia ColomboCrizia Colombo https://orcid.org/0000-0001-9943-8309 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Veronica LioVeronica Lio https://orcid.org/0000-0003-2773-5798 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Giulia RendaGiulia Renda G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Melissa FogliettaMelissa Foglietta https://orcid.org/0000-0001-7260-4661 G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Ivan PetrilliIvan Petrilli https://orcid.org/0000-0002-8545-812X G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Damiano D'ArdesDamiano D'Ardes G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Pier Paolo SainaghiPier Paolo Sainaghi https://orcid.org/0000-0001-8322-9158 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Gianluca AimarettiGianluca Aimaretti https://orcid.org/0000-0002-6186-0106 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Mattia BellanMattia Bellan https://orcid.org/0000-0003-1488-8736 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Luigi CastelloLuigi Castello https://orcid.org/0000-0001-8248-1976 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Gian Carlo AvanziGian Carlo Avanzi https://orcid.org/0000-0001-7611-8345 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Francesco Della CorteFrancesco Della Corte https://orcid.org/0000-0003-1736-2318 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Marco KrengliMarco Krengli https://orcid.org/0000-0002-2064-8379 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Mario PirisiMario Pirisi https://orcid.org/0000-0001-9740-0155 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Mario MalerbaMario Malerba Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Sant'Andrea Hospital, Vercelli, Italy (M. Malerba). , Andrea CapponiAndrea Capponi https://orcid.org/0000-0003-2822-3313 Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). , Sabina GallinaSabina Gallina https://orcid.org/0000-0003-0263-4851 G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Sante Donato PierdomenicoSante Donato Pierdomenico https://orcid.org/0000-0001-8038-9076 G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). , Francesco CipolloneFrancesco Cipollone G. d'Annunzio University, Chieti-Pescara. Ospedale Santissima Annunziata of Chieti (G.R., M.F., I.P., D.D., S.G., S.D.P., F.C.). and Giuseppe PattiGiuseppe Patti Correspondence to: Giuseppe Patti, MD, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità Hospital, Via Solaroli 17, Novara (NO), 28100, Italy. Email E-mail Address: [email protected] https://orcid.org/0000-0002-5404-3968 Università del Piemonte Orientale, Novara (E.G.S., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., M. Malerba, G.P.). Maggiore della Carità Hospital, Novara (E.G.S., M. Mennuni, A.R., L.G., C.C., V.L., P.P.S., G.A., M.B., L.C., G.C.A., F.D.C., M.K., M.P., A.C., G.P.). and the COVID-UPO Clinical Team† Originally published16 Feb 2021https://doi.org/10.1161/CIRCEP.120.009375Circulation: Arrhythmia and Electrophysiology. 2021;14:e009375Atrial fibrillation (AF) shares with coronavirus infective disease-19 (COVID-19) a higher prevalence of older age, cardiovascular risk factors, and comorbidities.1–3 Among patients with COVID-19, a history of AF is reported in ≈20% of cases,4 and new-onset AF represents a common complication, especially in those with a more severe disease.1–3 We specifically investigated the prognostic role of AF on in-hospital outcome in consecutive patients admitted for COVID-19 in 3 Italian Institutions (Hospitals of Novara, Vercelli, and Chieti).We retrospectively included consecutive patients aged ≥18 years hospitalized for COVID-19 from February to May 2020. The study protocol was approved by the institutional ethical committee (Institutional Review Board code CE 97/20), and patients gave informed consent to participate. All patients received a 12-lead ECG on admission. Additional electrocardiograms were performed every 48 hours in patients receiving QT-interval prolonging drugs (>90% of the whole population) or when clinically indicated. Patients were divided according to presence (either historical or new-onset) or absence of AF during the hospitalization for COVID-19. Historical AF was defined as a past medical history of AF.Primary end point was in-hospital all-cause mortality in patients with versus those without AF and in patients with different AF subtypes (historical and new-onset) versus those without AF. The following end points were also evaluated during in-hospital stay: cardiovascular mortality and severe acute respiratory distress syndrome. Logistic regression models were used to estimate the independent association between AF and study end points, including demographic factors, comorbidities, laboratory findings, and in-hospital treatments.A total of 637 patients were enrolled; 503 (79%) patients had no AF, and 134 (21%) had in-hospital AF (historical in 79 patients and new-onset in 55). Compared with patients without AF, those with AF were older and presented a higher prevalence of female sex, arterial hypertension, diabetes, cardiomyopathy, peripheral artery disease, chronic kidney disease, and chronic obstructive pulmonary disease. White blood cell count and C-reactive protein were increased and PaO2/FiO2 was reduced in the subset with new-onset versus historical AF.In-hospital mortality was higher in patients with AF (44.4% versus 22.1% in those without, P=0.001); 30-day estimated survival rates by Kaplan-Meier method were 39.6% (95% CI, 27.8%–50.8%) versus 59.4% (51.4%–66.5%), respectively (log-rank P 3 (N=285): 41.1% versus 32.3%, 8.8% absolute increase (P for interaction 0.02).Patients with new-onset AF showed an increased incidence of in-hospital death (49.1% versus 36.7%), cardiovascular mortality (14.6% versus 5.1%), and severe acute respiratory distress syndrome (49.1% versus 29.7%) compared with those with historical AF. The 30-day estimated survival rates were 44.3% (95% CI, 27.7%–59.6%) in patients with historical AF (P=0.007 versus no AF) and 30.8% (17.4%–45.2%) in those with new-onset AF (P<0.001 versus no AF; Figure [B]). Using patients without AF as reference, logistic regression analysis indicated a significant increase in the risk of all-cause death in those with new-onset AF (OR, 3.34 [95% CI, 1.54–7.25]; P=0.002); the increase was not significant in patients with historical AF (OR, 1.26 [95% CI, 0.58–2.74]; P=0.55).This study indicates that AF, especially new-onset, is an independent predictor of in-hospital all-cause mortality, cardiovascular death, and more severe clinical pattern in patients admitted for COVID-19. Given the risk of residual confounding, such association does not prove causation, as AF can be only a risk marker. Nevertheless, multiple adjustments for potential confounders and the finding that in-hospital AF was associated with lower survival mainly in patients with low or intermediate CHA2DS2-VASc score (ie, with fewer comorbidities) support that AF might, at least in part, directly impact mortality. Furthermore, patients with new-onset AF had a more severe COVID-19 presentation. This supports that new-onset AF is related to the degree of inflammatory and hypoxemic viral insult, and may further enhance the hypercoagulable state, endothelial dysfunction, and oxidative stress of COVID-19 patients, with consequent worsening in prognosis. The authors will make the data, methods used in the analysis, and materials used to conduct the research available to any researcher for purposes of reproducing the results.Nonstandard Abbreviations and AcronymsAFatrial fibrillationCOVID-19coronavirus infective disease-19ORodds ratioSources of FundingNoneAppendixThe following investigators also participated the COVID-UPO Clinical Team: Emanuele Albano: Umberto Dianzani, Gianluca Gaidano, Alessandra Gennari, Carla Gramaglia, Martina Solli, Ailia Giubertoni, Alessia Veia, Carlo Cisari, Paolo Amedeo Tillio, Paolo Aluffi Valletti, Francesco Barone Adesi, Michela Barini, Daniela Ferrante, Simona De Vecchi, Matteo Santagostino, Antonio Acquaviva, Elisa Calzaducca, Francesco Giuseppe Casciaro, Federico Ceruti, Micol Giulia Cittone, Davide Di Benedetto, Ileana Gagliardi, Greta Maria Giacomini, Irene Cecilia Landi, Raffaella Landi, Giulia Francesca Manfredi, Anita Rebecca Pedrinelli, Cristina Rigamonti, Eleonora Rizzi, Carlo Smirne, Veronica Vassia, Roberto Arioli, Pietro Danna, Zeno Falaschi, Alessio Paschè, Ilaria Percivale, Domenico Zagaria, Michela Beltrame, Matteo Bertoli, Alessandra Galbiati, Clara Ada Gardino, Maria Luisa Gastaldello, Valentina Giai Via, Francesca Giolitti, Ilaria Inserra, Emanuela Labella, Ilaria Nerici, Laura Cristina Gironi, Edoardo Cammarata, Elia Esposto, Vanessa Tarantino, Elisa Zavattaro, Francesca Zottarelli, Tommaso Daffara, Alice Ferrero, Ilaria Leone, Alessandro Nuzzo, Giulia Baldon, Sofia Battistini, Emilio Chirico, Luca Lorenzini, Maria Martelli, Emanuela Barbero, Paolo Boffano, Matteo Brucoli, Massimiliano Garzaro, Alberto Pau, Stephanie Bertolin, Letizia Marzari, Gianluca Avino, Massimo Saraceno, Umberto Morosini, Alessio Baricich, Marco Invernizzi, Silvia Gallo, Claudia Montabone, Samuel Alberto Padelli, Lucio Boglione, Filippo Patrucco, Luigia Salamina, Francesca Baorda, Eleonora Croce, Irene Giacone.Disclosures None.Footnotes*Drs Spinoni and Mennuni contributed equally to this work.†A list of all COVID-UPO Clinical Team members is given in the Appendix.For Sources of Funding and Disclosures, see page 214.Correspondence to: Giuseppe Patti, MD, Department of Translational Medicine, Università del Piemonte Orientale, Maggiore della Carità Hospital, Via Solaroli 17, Novara (NO), 28100, Italy. Email giuseppe.patti@uniupo.itReferences1. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D'Acquisto F, et al. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.Cardiovasc Res. 2020; 116:1666–1687. doi: 10.1093/cvr/cvaa106CrossrefMedlineGoogle Scholar2. Palmieri L, Vanacore N, Donfrancesco C, Lo Noce C, Canevelli M, Punzo O, Raparelli V, Pezzotti P, Riccardo F, Bella A, et al; Italian National Institute of Health COVID-19 Mortality Group. Clinical characteristics of hospitalized individuals dying with COVID-19 by age group in Italy.J Gerontol A Biol Sci Med Sci. 2020; 75:1796–1800. doi: 10.1093/gerona/glaa146CrossrefMedlineGoogle Scholar3. Inciardi RM, Adamo M, Lupi L, Cani DS, Di Pasquale M, Tomasoni D, Italia L, Zaccone G, Tedino C, Fabbricatore D, et al. Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy.Eur Heart J. 2020; 41:1821–1829. doi: 10.1093/eurheartj/ehaa388CrossrefMedlineGoogle Scholar4. Bhatla A, Mayer MM, Adusumalli S, Hyman MC, Oh E, Tierney A, Moss J, Chahal AA, Anesi G, Denduluri S, et al. COVID-19 and cardiac arrhythmias.Heart Rhythm. 2020; 17:1439–1444. doi: 10.1016/j.hrthm.2020.06.016CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Zając A, Wrona E and Kasprzak J (2024) Permanent and Persistent Atrial Fibrillations Are Independent Risk Factors of Mortality after Severe COVID-19, Journal of Clinical Medicine, 10.3390/jcm13113112, 13:11, (3112) Rathore S, Atulkar A, Remala K, Corrales V, Farrukh A, Puar R, Yao S, Ganipineni V, Patel N, Thota N, Kumar A and Deshmukh A (2024) A systematic review and meta‐analysis of new‐onset atrial fibrillation in the context of COVID‐19 infection, Journal of Cardiovascular Electrophysiology, 10.1111/jce.16169, 35:3, (478-487), Online publication date: 1-Mar-2024. Ko D, Treu T, Tarko L, Ho Y, Preis S, Trinquart L, Gagnon D, Monahan K, Helm R, Orkaby A, Lubitz S, Bosch N, Walkey A, Cho K, Wilson P and Benjamin E (2024) Incidence and prognostic significance of newly-diagnosed atrial fibrillation among older U.S. veterans hospitalized with COVID-19, Scientific Reports, 10.1038/s41598-024-51177-6, 14:1 Brito J, Caldeira D, Gregório C, Plácido R and Pinto F (2024) Arterial Hypertension, Heart Failure, Angina Pectoris, Myocardial Infarction, and Atrial Fibrillation after COVID-19: A Narrative Review, Heart and Mind, 10.4103/hm.HM-D-23-00040, 8:2, (81-88), . de la Torre Fonseca L, Cedeño R, Díaz V, Cedeño F and Juan-Salvadores P (2023) Cardiovascular Complications in Patients Hospitalized for COVID-19: A Cohort Study in Havana, Cuba, Cardiovascular Revascularization Medicine, 10.1016/j.carrev.2023.02.014, 52, (10-15), Online publication date: 1-Jul-2023. Jurisic S, Komminoth M, Todorov A, Bertschi D, Jurisic M, Vranjic I, Wiggli B, Schmid H, Gebhard C, Gebhard C, Heidecker B, Beer J and Patriki D (2023) Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19, Journal of Clinical Medicine, 10.3390/jcm12082925, 12:8, (2925) Duan S and Du J (2023) Sinus node dysfunction and atrial fibrillation—Relationships, clinical phenotypes, new mechanisms, and treatment approaches, Ageing Research Reviews, 10.1016/j.arr.2023.101890, 86, (101890), Online publication date: 1-Apr-2023. Huseynov A, Akin I, Duerschmied D and Scharf R (2023) Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment, Viruses, 10.3390/v15020389, 15:2, (389) Donniacuo M, De Angelis A, Rafaniello C, Cianflone E, Paolisso P, Torella D, Sibilio G, Paolisso G, Castaldo G, Urbanek K, Rossi F, Berrino L and Cappetta D (2023) COVID-19 and atrial fibrillation: Intercepting lines, Frontiers in Cardiovascular Medicine, 10.3389/fcvm.2023.1093053, 10 Rojas-García M, Vázquez B, Torres-Poveda K and Madrid-Marina V (2023) Lethality risk markers by sex and age-group for COVID-19 in Mexico: a cross-sectional study based on machine learning approach, BMC Infectious Diseases, 10.1186/s12879-022-07951-w, 23:1 Renda G, Mennuni M, Pizzoferrato G, Esposto D, Alberani A, De Vecchi S, Degiovanni A, Giubertoni A, Spinoni E, Grisafi L, Sagazio E, Ucciferri C, Falasca K, Vecchiet J, Gallina S and Patti G (2023) Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19, Diagnostics, 10.3390/diagnostics13020224, 13:2, (224) Bernstein H, Paciotti B and Srivatsa U (2023) Incidence and implications of atrial fibrillation in patients hospitalized for COVID compared to non-COVID pneumonia: A multicenter cohort study, Heart Rhythm O2, 10.1016/j.hroo.2022.10.012, 4:1, (3-8), Online publication date: 1-Jan-2023. Vardavas C, Mathioudakis A, Nikitara K, Stamatelopoulos K, Georgiopoulos G, Phalkey R, Leonardi-Bee J, Fernandez E, Carnicer-Pont D, Vestbo J, Semenza J, Deogan C, Suk J, Kramarz P, Lamb F and Penttinen P (2022) Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe, European Respiratory Review, 10.1183/16000617.0098-2022, 31:166, (220098), Online publication date: 31-Dec-2022. Aydemir S, Aksakal E, Aydınyılmaz F, Gülcü O, Saraç İ, Aydın S, Doğan R, Lazoğlu M and Kalkan K (2022) Does new onset and pre-existing atrial fibrillation predict mortality in COVID-19 patients?, The Egyptian Heart Journal, 10.1186/s43044-022-00291-9, 74:1, Online publication date: 1-Dec-2022. Kassis N, Kumar A, Gangidi S, Milinovich A, Kalra A, Bhargava A, Menon V, Wazni O, Rickard J and Khot U (2022) Prognostic value of initial electrocardiography in predicting long-term all-cause mortality in COVID-19, Journal of Electrocardiology, 10.1016/j.jelectrocard.2022.10.003, 75, (1-9), Online publication date: 1-Nov-2022. Wollborn J, Karamnov S, Fields K, Yeh T and Muehlschlegel J (2022) COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients, Scientific Reports, 10.1038/s41598-022-16113-6, 12:1 Rosenblatt A, Ayers C, Rao A, Howell S, Hendren N, Zadikany R, Ebinger J, Daniels J, Link M, de Lemos J and Das S (2022) New-Onset Atrial Fibrillation in Patients Hospitalized With COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Registry, Circulation: Arrhythmia and Electrophysiology, 15:5, (e010666), Online publication date: 1-May-2022. Satterfield B, Bhatt D and Gersh B (2021) Cardiac involvement in the long-term implications of COVID-19, Nature Reviews Cardiology, 10.1038/s41569-021-00631-3, 19:5, (332-341), Online publication date: 1-May-2022. Ajmera K (2022) Adverse Events Profile of COVID-19 Preventative Strategies, Encyclopedia, 10.3390/encyclopedia2010028, 2:1, (457-465) Renda G, Ricci F, Spinoni E, Grisafi L, D'Ardes D, Mennuni M, Tana C, Rognoni A, Bellan M, Sainaghi P, Pirisi M, De Vecchi S, Gallina S, Pierdomenico S, Cipollone F and Patti G (2022) Predictors of Mortality and Cardiovascular Outcome at 6 Months after Hospitalization for COVID-19, Journal of Clinical Medicine, 10.3390/jcm11030729, 11:3, (729) Fumagalli S, Trevisan C, Del Signore S, Pelagalli G, Fumagalli C, Herbst A, Volpato S, Gareri P, Mossello E, Malara A, Monzani F, Okoye C, Coin A, Bellelli G, Zia G, Ungar A, Ranhoff A and Antonelli Incalzi R (2021) Atrial fibrillation and COVID-19 in older patients: how disability contributes to shape the risk profile. An analysis of the GeroCovid registry, Aging Clinical and Experimental Research, 10.1007/s40520-021-02008-5, 34:1, (249-256), Online publication date: 1-Jan-2022. Chen M, Xiao F, Kuai L, Zhou H, Jia Z, Liu M, He H and Hong M (2021) Outcomes of atrial fibrillation in patients with COVID-19 pneumonia: A systematic review and meta-analysis, The American Journal of Emergency Medicine, 10.1016/j.ajem.2021.09.050, 50, (661-669), Online publication date: 1-Dec-2021. Zuin M, Rigatelli G, Bilato C, Zanon F, Zuliani G and Roncon L (2021) Pre-existing atrial fibrillation is associated with increased mortality in COVID-19 Patients, Journal of Interventional Cardiac Electrophysiology, 10.1007/s10840-021-00992-2, 62:2, (231-238), Online publication date: 1-Nov-2021. Romiti G, Corica B, Lip G and Proietti M (2021) Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis, Journal of Clinical Medicine, 10.3390/jcm10112490, 10:11, (2490) February 2021Vol 14, Issue 2 Advertisement Article InformationMetrics © 2021 American Heart Association, Inc.https://doi.org/10.1161/CIRCEP.120.009375PMID: 33591815 Originally publishedFebruary 16, 2021 Keywordsatrial fibrillationCOVID-19hospitalmortalityrisk factorPDF download Advertisement SubjectsAtrial FibrillationCardiovascular Disease
Referência(s)