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Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)

2021; Taylor & Francis; Volume: 81; Issue: 3 Linguagem: Inglês

10.1080/00365513.2021.1881997

1502-7686

Luis García de Guadiana‐Romualdo, Daniel Morell‐García, Cristian Morales‐Indiano, Josep Miquel Bauçà, Maria José Alcaide Martín, C. Esparza Del Valle, José Ignacio Gutiérrez Revilla, Eloísa Urrechaga, J.M. Álamo-Martínez, Ana María Hernando Holgado, María-Carmen Lorenzo-Lozano, Silvia Sánchez Fdez‐Pacheco, Patricia de la Hera Cagigal, María Ángeles Juncos Tobarra, Juan A. Vílchez, Isabel Vírseda Chamorro, Irene Gutiérrez García, Yolanda Pastor Murcia, L. Frías, Laura Altimira Queral, Elisa Nuez‐Zaragoza, Juan Adell Ruiz de León, Alicia Ruiz Ripa, Paloma Salas Gómez‐Pablos, Iria Cebreiros López, Amaia Fernandez-Uriarte, Álex Larruzea, María Luisa López Yepes, Patricia Esteban Torrella, María C. Zamorano Andrés, José Pedregosa Díaz, Cristina Acevedo Alcaraz, A.L. Blázquez Manzanera, Ana María Lourdes Padilla Jiménez, María C. Baamonde Calzada, Marina Vera, Matilde Cháfer Rudilla, Magdalena Canalda Campás, Sara García Muñoz, Luis Vicente Gutiérrez, Laura Jiménez Añón, Alfonso Pérez Martínez, Aurelio Pons Castillo, Ruth González Tamayo, J. Vivancos, Olaia Rodríguez‐Fraga, Vicente Ferrer Díaz de Brito Fernández, Vicente Aguadero, María Gloria García Arévalo, María Arnaldos Carrillo, Mercedes González Morales, María Núñez Gárate, Cristina Ruiz Iruela, Natalia Sancho‐Rodríguez, Martí Vila Pérez, José M. Egea-Caparrós, Luis Felipe Loaiza Sáenz, Álvaro Blasco Barbero, Amparo Galán Ortega,

COVID-19 and healthcare impacts

Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.