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BIBTEX RIS

Adipocytokine and appetite-regulating hormone response to weight loss in adolescents with obesity: Impact of weight loss magnitude

2021; Elsevier BV; Volume: 87-88; Linguagem: Inglês

10.1016/j.nut.2021.111188

1873-1244

Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Luciana Oliveira e Silva, Yasmin Alaby Martins Ferreira, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Lila Missae Oyama, Lian Tock, Marco Túlio de Mello, Sérgio Tufik, David Thivel, Ana Raimunda Dâmaso,

Adipose Tissue and Metabolism

The aim of this study was to investigate the association between the magnitude of weight loss (WL) and serum concentrations of the main adipocytokines and appetite-regulating hormones in adolescents with obesity. After completion of informed consent,108 adolescents with obesity (14–19 y of age; postpubertal) were submitted to clinical, nutritional, psychological, physical exercise, and physiotherapy support for 1 y. Body composition (BC) and plasma levels of neuropeptides (neuropeptide Y [NPY], agouti-related peptide [AgRP], and α-melanocyte-stimulating hormone [α-MSH]) and leptin were measured at baseline and post-intervention. After therapy, adolescents who lost <10% body weight and 10% seems to reverse obesity-induced hyperleptinemia while stabilizing the neuropeptides that control appetite in adolescents with obesity. We were able to produce a prognostic mathematical model to predict body fat loss using weight, leptin, and α-MSH variations.