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Temporal trends of SARS-CoV-2 seroprevalence in transfusion blood donors during the first wave of the COVID-19 epidemic in Kenya

2021; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2021.02.09.21251404

Ifedayo Adetifa, Sophie Uyoga, John N. Gitonga, Daisy Mugo, Mark Otiende, James Nyagwange, Henry Karanja, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Wangari Ng’ang’a, Charles Rombo, Christine Yegon, Khamisi Kithi, Elizabeth Odhiambo, Thomas Rotich, Irene Orgut, Sammy Kihara, Christian Bottomley, E. Wangeci Kagucia, Katherine E. Gallagher, Anthony Etyang, Shirine Voller, Teresa Lambe, Daniel Wright, Edwine Barasa, Benjamin Tsofa, Philip Bejon, Lynette Isabella Ochola‐Oyier, Ambrose Agweyu, J. Anthony G. Scott, George M. Warimwe,

COVID-19 epidemiological studies

Abstract Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.