Portal de Periódicos da CAPES

Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis

2021; SAGE Publishing; Volume: 27; Issue: 10 Linguagem: Inglês

10.1177/1352458520978354

1477-0970

Lis Campos Ferreira, Nise Alessandra de Carvalho Sousa, Maria Lúcia Brito Ferreira, Rafael Paternò Castello Dias-Carneiro, María Fernanda Mendes, Ana Cláudia Piccolo, Rodrigo Barbosa Thomaz, Cláudia Cristina Ferreira Vasconcelos, Soniza Vieira Alves‐Leon, Gutemberg Augusto Cruz dos Santos, Valéria Coelho Santa Rita Pereira, Enedina Maria Lobato de Oliveira, Samira Luísa Apóstolos‐Pereira, Mateus Boaventura de Oliveira, Caio César Diniz Disserol, Herval Ribeiro Soares Neto, Gabriela J. Martins, José Artur Costa d’Almeida, Milena Sales Pitombeira, Lucas Silvestre Mendes, Mário Emílio Teixeira Dourado Júnior, Bianca Etelvina Santos de Oliveira, D. Guerra, Maria Íris de Morais Machado, Alvaro Jose Porto Moreira, Thiago Gonçalves Fukuda, Hideraldo Luís Souza Cabeça, Luciano Chaves Rocha, Maria Cecília Aragon de Vecino, Camila Batista Oliveira Silva, Leizian de Souza Amorim, Andréa Anacleto Ferrari de Castro, Antônio Pereira Gomes Neto, Maria Sheila Guimarães Rocha, Sidney Gomes, Heloísa Helena Ruocco, Yára Dadalti Fragoso, Marcus Vinícius Magno Gonçalves, Maria Lúcia Vellutini Pimentel, Suzana Nunes Machado, Omar Gurrola Arambula, Anderson Kuntz Grzesiuk, Damacio Ramón Kaimen-Maciel, Denise Sisterolli Diniz, Elizabeth Regina Comini-Frota, Guilherme Sciascia do Olival, Ronaldo Maciel Dias, Luiz Domingos Mendes Melges, Paulo Diniz da Gama, Marlise de Castro Ribeiro, Rogério de Rizo Morales, Ana Carolina Amaral de Andrade, Heloise Helena Siqueira, Mônica Koncke Fiuza Parolin, Henry Koity Sato, José Alexandre Figueiredo, Leandro Cortoni Calia, L Scolari, Carlos Alberto Magirius Peixoto, Vera Lúcia Ferreira Vieira, Renata Leite Menon, Marlos Aureliano Dias de Sousa, Silvana Sobreira, Taysa A Gonsalves Jubé Ribeiro, Vanessa Maia Costa, Carla Renata Aparecida Vieira Stella, Fernando Elias Borges, Adaucto Wanderley da Nóbrega, Dagoberto Callegaro, Eduardo Antônio Donadi, Tarso Adoni, Rafael de Castro Catão, Carlos Magno Castelo Branco Fortaleza, Hélio Amante Miot, Edmur Azevedo Pugliesi, Raúl Borges Guimarães, Felipe von Glehn, Doralina Guimarães Brum,

Polyomavirus and related diseases

Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS).To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS.This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020.The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs.Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment.