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Orofacial features in children with microcephaly associated with Zika virus: A scoping review

2021; Wiley; Volume: 28; Issue: 4 Linguagem: Inglês

10.1111/odi.13804

1601-0825

Adriano Referino da Silva Sobrinho, Letícia Francine Silva Ramos, Ytalo Lourenço Maciel, Hérika de Arruda Maurício, Renata de Oliveira Cartaxo, Stefânia Jerônimo Ferreira, Pedro Henrique Sette‐de‐Souza,

Virology and Viral Diseases

Abstract Objective To analyze published scientific evidence about the most common orofacial disorders in children with microcephaly associated with ZIKV infection. Methods Through a scoping review, we respond to the search question was formulated: "What are the orofacial alterations in children with microcephaly associated with ZIKV?" It was performed a search in PubMed, EMBASE, Scopus, and Health Virtual Library. It was selected papers wrote in English, Portuguese, or Spanish. An evidence quality analysis was performed using the Agency for Healthcare Research and Quality classification. Results It was included 11 studies performed in the Brazilian Northeast region. The studies were carried out between 2018 and 2020. The main related alterations were delay in the tooth‐eruption and deformation in the oral structures. Conclusion The results observed in our work show moderate scientific evidence regarding the association of ZIKV with orofacial alterations in children with microcephaly due to the classifications of the quality of evidence of each one of the included studies. The main changes reported were in the chronology of tooth eruption, alteration in teeth, and oral structures.