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The T-cell response to SARS-CoV-2: kinetic and quantitative aspects and the case for their protective role

2021; Oxford University Press; Volume: 2; Issue: 1 Linguagem: Inglês

10.1093/oxfimm/iqab006

2633-6960

Antonio Bertoletti, Anthony T. Tan, Nina Le Bert,

Long-Term Effects of COVID-19

Abstract Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), the etiological agent of Coronavirus Diseases 2019 (COVID-19), triggers an adaptive immunity in the infected host that results in the production of virus-specific antibodies and T cells. Although kinetic and quantitative aspects of antibodies have been analyzed in large patient cohorts, similar information about SARS-CoV-2-specific T cells are scarce. We summarize the available knowledge of quantitative and temporal features of the SARS-CoV-2 T-cell response in this review. Currently, most of the data are derived only from the analysis of the circulatory compartment. Despite this limitation, early appearance, multi-specificity and functionality of SARS-CoV-2-specific T cells are associated with accelerated viral clearance and with protection from severe COVID-19.