Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe
2021; Multidisciplinary Digital Publishing Institute; Volume: 26; Issue: 4 Linguagem: Inglês
10.3390/molecules26041094
ISSN1433-1373
AutoresMelissa M. Cadelis, Soeren Geese, Benedict Uy, Daniel R. Mulholland, Shara J. van de Pas, Alex Grey, Bevan Weir, Brent R. Copp, Siouxsie Wiles,
Tópico(s)Plant-Microbe Interactions and Immunity
ResumoAntimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.
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