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Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms

2021; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 2 Linguagem: Inglês

10.3390/cells10020477

2073-4409

Marceau Quatredeniers, Pedro Mendes‐Ferreira, Diana Santos‐Ribeiro, Morad K. Nakhleh, Maria‐Rosa Ghigna, Sylvia Cohen‐Kaminsky, Frédéric Perros,

Hemoglobinopathies and Related Disorders

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH.