Portal de Periódicos da CAPES

Consenso de hemofilia en México

2021; Academia Nacional de Medicina de México; Volume: 157; Issue: 91 Linguagem: Inglês

10.24875/gmm.m20000451

2696-1288

José L. López-Arroyo, Juan Manuel Pérez-Zúñiga, Laura Elizabeth Merino‐Pasaye, Azucena Saavedra-González, Luisa M. Alcivar-Cedeño, José L. Álvarez-Vera, Irene Anaya-Cuéllar, Luara L. Arana-Luna, David Ávila-Castro, Ramón A. Bates-Martín, Gabriela Cesarman‐Maus, Lénica A. Chávez-Aguilar, José A. de la Peña-Celaya, María Eugenia Espitia-Ríos, Patricia Estrada-Domínguez, Denisse J. Fermín-Caminero, Willy Flores-Patricio, Jaime García-Chávez, María Teresa García‐Lee, Ma. del Carmen González-Pérez, María del C. González-Rubio, Ma. Guadalupe González-Villareal, Fabiola Ramírez-Moreno, Ana K. Hernández-Colín, Eleazar Hernández-Ruiz, Wilfrido Herrera-Olivares, Faustino Leyto-Cruz, Sergio J. Loera-Fragoso, Juan J. Orellana-Garibay, Orlando G. Palma-Moreno, Eugenia Patricia Paredes-Lozano, Paula Peña-Alcántara, Uendy Pérez-Lozano, Yayra M. Pichardo-Cepín, Ana Carolina-Reynoso, Mishel Rodríguez-Serna, Flavio Rojas-Castillejos, Hilda Romero-Rodelo, Josué I. Ruíz-Contreras, Adela Segura-García, Karina Silva-Vera, Paulina M. Soto-Cisneros, Ana L. Tapia-Enríquez, Martha G. Tavera-Rodríguez, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, María D. Valencia-Rivas, Teresa Valle-Cárdenas, Ana Varela-Constantino, Adrián Javier-Morales, Mario A. Martínez-Ramírez, Sergio Tena-Cano, Ricardo Terrazas-Marín, Shendel P. Vilchis-González, Atenas Villela-Peña, Verónica Mena-Zepeda, Martha Alvarado‐Ibarra,

Hemostasis and retained surgical items

Hemophilia is a hemorrhagic disorder with a sex-linked inherited pattern, characterized by an inability to amplify coagulation due to a deficiency in coagulation factor VIII (hemophilia A or classic) or factor IX (hemophilia B).Sequencing of the genes involved in hemophilia has provided a description and record of the main mutations, as well as a correlation with the various degrees of severity.Hemorrhagic manifestations are related to levels of circulating factor, mainly affecting the musculoskeletal system and specifically the large joints (knees, ankles, and elbows).This document is a review and consensus of the main genetic aspects of hemophilia, from the inheritance pattern to the concept of women carriers, physiopathology and classification of the disorder, the basic and confirmation studies when hemophilia is suspected, the various treatment regimens based on infusion of the deficient coagulation factor as well as innovative factor-free therapies and recommendations for the management of complications associated with treatment (development of inhibitors and/or transfusion-transmitted infections), or secondary to articular hemorrhagic events (hemophilic arthropathy).Finally, relevant reviews of clinical and treatment aspects of hemorrhagic pathology characterized by acquired deficiency of FVIII secondary to neutralized antibodies named acquired hemophilia.