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BIBTEX RIS

COVID-19 epidemic in the Brazilian state of Amazonas was driven by long-term persistence of endemic SARS-CoV-2 lineages and the recent emergence of the new Variant of Concern P.1

2021; Research Square (United States); Linguagem: Inglês

10.21203/rs.3.rs-275494/v1

Autores

Felipe Gomes Naveca, Valdinete Alves do Nascimento, Victor Francisco de Souza, André de Lima Guerra Corado, Fernanda Nascimento, George Silva, Ágatha Costa, Débora Duarte, Karina Pessoa, Matilde Mejía, Maria Girlane Sousa Albuquerque Brandão, Michele Silva de Jesus, Luciana Gonçalves, Cristiano Fernandes da Costa, Vanderson de Souza Sampaio, Daniel Ribeiro de Barros, Marineide Silva, Tirza Mattos, Gemilson Soares Pontes, Lígia Fernandes Abdalla, João Santos, Ighor Arantes, Filipe Zimmer Dezordi, Marilda Mendonça Siqueira, Gabriel Luz Wallau, Paola Cristina Resende, Edson Delatorre, Tiago Gräff, Gonzalo Bello,

Tópico(s)

Virology and Viral Diseases

Resumo

Abstract The Northern Brazilian state of Amazonas is one of the most heavily affected country regions by the COVID-19 epidemic and experienced two exponential growing waves in early and late 2020. Through a genomic epidemiology study based on 250 SARS-CoV-2 genomes from different Amazonas municipalities sampled between March 2020 and January 2021 we revealed that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195 which was gradually replaced by lineage B.1.1.28. The second wave coincides with the emergence of the variant of concern (VOC) P.1 which evolved from a local B.1.1.28 clade in late November and rapidly replaced the parental lineage in less than two months. Our findings support that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1 virus. These data provide unique insights to understanding the mechanisms that underlie the COVID-19 epidemic waves and the risk of disseminating SARS-CoV-2 VOC P.1 in Brazil and potentially worldwide.

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