Produção Nacional
Revisado por pares
First report on the Annona exsucca DC. Essential oil and in silico identification of potential biological targets of its major compounds
2021; Taylor & Francis; Volume: 36; Issue: 15 Linguagem: Inglês
10.1080/14786419.2021.1893724
ISSN1478-6427
AutoresMárcia Moraes Cascaes, Sebastião Gomes Silva, Jorddy Neves Cruz, Mozaniel Santana de Oliveira, Jorge Oliveira, Ângelo Antônio Barbosa de Moraes, Fernando Augusto Miranda da Costa, Kauȇ Santana da Costa, Lidiane Diniz do Nascimento, Eloísa Helena de Aguiar Andrade,
Tópico(s)Piperaceae Chemical and Biological Studies
ResumoIn the present study, the essential oil (EO) of Annona exsucca DC. or Rollinia exsucca was extracted by hydrodistillation, and the identification and quantification of volatile compounds were performed by GC-MS and GC-FID. A. exsucca leaves were collected from the Magalhães Barata, northeast of the State of Pará (Brazil) in March and September of 2019. Moreover, we used computational approaches to evaluate possible biological targets for the major compounds of the EO. In the sample obtained in March, 50 compounds were identified, with hydrocarbon sesquiterpenes being the predominant ones with the content of 80.52%. In the sample collected in September, 58 compounds were identified, and the chemical class of hydrocarbon monoterpenes and sesquiterpenes were the dominant ones with contents of 43.36 and 31.29%, respectively. Computational methods demonstrated that some major compounds have potential biological activity against some strains of pathogenic bacteria, as well as against molecular targets involved in cancer development.
Referência(s)