Produção Nacional
Revisado por pares
Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês
10.1038/s41598-021-93691-x
ISSN2045-2322
AutoresRossana Santiago de Sousa Azulay, Luís Cristóvão Pôrto, Silva Da, Maria da Glória Tavares, Roberta Maria Duailibe Ferreira Reis, Gilvan Cortês Nascimento, Sabrina da Silva Pereira Damianse, Viviane Chaves de Carvalho Rocha, Marcelo Magalhäes, Vandílson Pinheiro Rodrigues, Paulo Ricardo Vilas Boas Carvalho, Manuel dos Santos Faria, Marília Brito Gomes,
Tópico(s)Digestive system and related health
ResumoAbstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1 , -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.
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