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Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2

2021; Oxford University Press; Volume: 224; Issue: 6 Linguagem: Inglês

10.1093/infdis/jiab127

1537-6613

Ludivine Grzelak, Aurélie Velay, Yoann Madec, Floriane Gallais, Isabelle Staropoli, Catherine Schmidt‐Mutter, Marie-Josée Wendling, Nicolás Meyer, Cyril Planchais, David Rey, Hugo Mouquet, Nathalie Reix, Ludovic Glady, Yves Hansmann, Timothée Bruel, de Sèze, Arnaud Fontanet, Maria Gonzalez, Olivier Schwartz, Samira Fafi‐Kremer,

Infection Control and Ventilation

Abstract We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m2. At months 3–6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.