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The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

2021; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 3 Linguagem: Inglês

10.3390/ph14030237

1424-8247

François Pognan, Thomas Steger‐Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutiérrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Güney, Jan A. Kors, Miguel Ángel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez‐Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik M. van Mulligen, Ferrán Sanz,

Genetics, Bioinformatics, and Biomedical Research

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.