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Front Cover: Late‐stage Rh(II)‐catalyzed Nitrene Transfer for the Synthesis of Guaianolide Analogs with Enhanced Antiproliferative Activity (12/2021)

2021; Wiley; Volume: 2021; Issue: 12 Linguagem: Inglês

10.1002/ejoc.202100297

1434-193X

Sebastián J. Castro, José M. Padrón, Benjamin Darses, Viviana E. Nicotra, Philippe Dauban,

Traditional and Medicinal Uses of Annonaceae

The Front Cover shows the Stevia plant (Stevia yaconensis var. subeglandulosa Hieron) from which Ludartin is isolated. Catalytic C(sp3)–H amination at the C-2 position of Ludartin provides new analogs of guaianolides with improved antiproliferative properties. Dr. F. Zuloaga and Dr M. Belgrano from Instituto de Botánica Darwinion, San Isidro, Buenos Aires, are gratefully acknowledged for the picture. More information can be found in the Communication by S. J. Castro, V. E. Nicotra, P. Dauban et al.