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Normothermic Liquid Ventilation Attenuates Inflammation from Ischemia-Reperfusion Injury in an Ex Vivo Rat Model

2021; Elsevier BV; Volume: 40; Issue: 4 Linguagem: Inglês

10.1016/j.healun.2021.01.971

1557-3117

Daniela Becerra, HM Linge, S.C. Jeffs, Scott J. Roberts, J. O, Harald C. Ott,

Cardiac Ischemia and Reperfusion

Results: Patient discharged on multi-agent regimen with plan to complete 6-month course of IV L-AmB, followed by lifelong oral isavuconazole and inhaled L-AmB.Subsequent TBBx without evidence of mucormycosis.Conclusion: Delays in diagnosis and treatment of mucormycosis is lifethreatening, especially in the native lung after single LTx.Patient likely failed oral isavuconazole monotherapy due to decreased blood supply to native lung after single LTx.Inhaled antifungals in conjunction with early surgical intervention should be considered along with standard medical management for LTR with mucormycosis.