Artigo Acesso aberto Revisado por pares

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability

2021; American Association for the Advancement of Science; Volume: 7; Issue: 13 Linguagem: Inglês

10.1126/sciadv.abf3072

ISSN

2375-2548

Autores

Yu Nagayoshi, Takeshi Chujo, S. Hirata, Hiroki Nakatsuka, Chien-Wen Chen, Mayuko Takakura, Kenjyo Miyauchi, Yoshiho Ikeuchi, Becky C. Carlyle, Robert R. Kitchen, Tsutomu Suzuki, Fumiki Katsuoka, Masayuki Yamamoto, Yu‐ichi Goto, Motomasa Tanaka, Kiyohisa Natsume, Angus C. Nairn, Tsutomu Suzuki, Kazuhito Tomizawa, Fan‐Yan Wei,

Tópico(s)

RNA Research and Splicing

Resumo

Defective tRNA 2′- O -modification impairs translation efficiency at Phe codon in the brain and induces a neurological dysfunction.

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