Steroid hormone modulates the production of cathelicidin and human β-defensins in lung epithelial cells and macrophages promoting Mycobacterium tuberculosis killing
2021; Elsevier BV; Volume: 128; Linguagem: Inglês
10.1016/j.tube.2021.102080
ISSN1873-281X
AutoresSara Paulina Marín-Luevano, Adrián Rodríguez-Carlos, Yolanda M. Jacobo-Delgado, Claudia Valdez-Miramontes, José Antonio Enciso‐Moreno, Bruno Rivas‐Santiago,
Tópico(s)Neuropeptides and Animal Physiology
ResumoSeveral studies have documented the interaction between the immune and endocrine systems as an effective defense strategy against tuberculosis, involving the production of several molecules and immunological processes. In this study, we determined the effect of cortisol and dehydroepiandrosterone (DHEA) on the production of antimicrobial peptides such as cathelicidin and human β-defensin (HBD) −2, and HBD-3 and their effect on intracellular growth of Mycobacterium tuberculosis ( Mtb ) in lung epithelial cells and macrophages. Our results showed that DHEA promotes the production of these antimicrobial peptides in infected cells, correlating with the decrease of Mtb bacilli loads. These results suggest the use of exogenous DHEA as an adjuvant for tuberculosis therapy.
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