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Elevated serum concentrations of S100–A11 and AIF-1 in cervical dysplasia patients

2021; Czech Medical Association of J. E. Purkyně; Volume: 86; Issue: 1 Linguagem: Inglês

10.48095/cccg202111

1805-4455

Martin Maděrka, Vladimír Dvořák, Jozef Hambálek, David Stejskal, G Krejčí, Marek Švesták, Kateřina Langová, R Pilka,

Cervical Cancer and HPV Research

Objective The aim of this study was to compare TFF3, AIF-1, S100-A11 and DKK1 serum levels in patients with cervical dysplasia, and in healthy female controls. Methods The first group included 59 patients with a histological dia-gnosis of precancerous disease CIN 1. The second group included 198 patients with a histological dia-gnosis of precancerous disease CIN 2 or CIN 3. The control group was comprised of 90 patients who underwent elective total hysterectomy for nonmalignant disorders. In all patients, preoperative serum samples were taken and separated; the sera were all stored at -80°C until the analysis for TFF3, AIF-1, S100-A11 and DKK1. Results The serum levels of S100-A11 (P l 0.0001) and AIF-1 (P l 0.0001) were statistically significantly higher in patients with mild precancerous lesions (CIN 1) than in controls. The levels of TFF3 and DKK1 were not statistically significantly different in patients with CIN 1 and in the control group. The serum levels of S100-A11 (P l 0.0001) and AIF-1 (P l 0.0001) were statistically significantly higher in patients with severe precancerous lesions (CIN 2/3) than in controls. TFF3 and DKK1 levels were not statistically significantly different in patients with CIN 2/3 compared to controls. Conclusion S100-A11 and AIF-1 represent potential bio-markers in patients with cervical dysplasia.