Enrichment of CCR6 + CD8 + T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19
2021; Wiley; Volume: 51; Issue: 6 Linguagem: Inglês
10.1002/eji.202049046
ISSN1521-4141
AutoresAnno Saris, Tom D. Y. Reijnders, Martine Reijm, Jolien C. Hollander, Kim de Buck, Alex R. Schuurman, JanWillem Duitman, Leo Heunks, Jurjan Aman, Harm Jan Bogaard, Esther J. Nossent, Tom van der Poll, Hetty J. Bontkes,
Tópico(s)SARS-CoV-2 and COVID-19 Research
ResumoDespite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
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