Portal de Periódicos da CAPES

Revisão Produção Nacional Revisado por pares

BIBTEX RIS

Nanofibers as drug-delivery systems for antimicrobial peptides

2021; Elsevier BV; Volume: 26; Issue: 8 Linguagem: Inglês

10.1016/j.drudis.2021.03.008

1878-5832

Maurício Gonçalves C. Sousa, Taia Maria Berto Rezende, Octávio Luiz Franco,

Graphene and Nanomaterials Applications

Microbial infections are a major worldwide public health problem because a number of microorganisms can show drug resistance. Antimicrobial peptides (AMPs) are small biomolecules that present antimicrobial and immunomodulatory activities. Despite their great potential, there are still many barriers to the formulation of these molecules. In this context, nanotechnological approaches such as nanofibers are candidate drug-delivery systems for AMP formulations. These nanomaterials have a large contact surface and may carry several AMPs (single or multilayer), directing them to specific targets. Thus, this review describes the main advances related to the use of nanofibers as drug-delivery systems for AMPs. These strategies can contribute directly to the design of new multifunctional wound dressings, coatings for prostheses, and tissue engineering applications.