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Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study

2021; Springer Science+Business Media; Volume: 73; Issue: 2 Linguagem: Inglês

10.1007/s12020-021-02758-2

1559-0100

Alessandro Pizzocaro, Paolo Colombo, Walter Vena, Salvatore Ariano, Paola Magnoni, Francesco Reggiani, Giuseppe Favacchio, Marco Mirani, Elisabetta Lavezzi, Antonio Voza, Marta Calatroni, Gherardo Mazziotti, Andrea Lania, Stefano Accornero, Alessio Aghemo, Ludovico Alfarone, Hussam Ali, Monia Aloise, Claudio Angelini, Ivan Arcari, Paola Arosio, Elena Azzolini, Alessandra Baccarin, Salvatore Badalamenti, Stéphanie Baggio, Luca Balzarini, Caterina Barberi, Franca Barbic, V. Barbieri, Alessandro Barbone, Alessio Basciu, Chiara Benvenuti, Ilaria Bianchi, M. Bocciolone, Cristiana Bonifacio, Federica Borea, Mario Borroni, Gianluigi Bresciani, Enrico Brunetta, C. Bulletti, Cristina Cadonati, Lorenzo Calabrò, Marta Calatroni, Giuseppe Caltagirone, Albania Calvetta, F. Cannata, Lorenzo Maria Canziani, Antonio Capogreco, Giovanni Capretti, Elisa Carlani, Flaminia Carrone, Maddalena Casana, Alice Castelli, Elena Castelnuovo, Angela Ceribelli, Carlo Ceriotti, Mauro Chiarito, Michele Ciccarelli, Matteo Cimino, Gianluigi Citterio, Leonardo Ciuffini, Chiara Colaizzi, Francesca Colapietro, Guido Costa, Ottavia Cozzi, Vincenzo Craviotto, Chiara Crespi, Massimo P. Crippa, Federica D’Antonio, Felice D’Antuono, Federico D’Orazio, Sara Dal Farra, Leonardo Da Rio, Guido De Ambroggi, Massimo De Donato, Francesca De Lucia, Pasquale De Nittis, Giacomo Delle Rose, Antonio Desai, Maria De Santis, Marina Di Pilla, Franca Dipaola, A. DiPasquale, Angelo Dipasquale, Ginevra Droandi, Roberta Fazio, Giuseppe Favacchio, Carlo Fedeli, Giuseppe Ferrante, E.C. Ferrara, Matteo Carlo Ferrari, Sebastian Ferri, Marco Folci, Sara Foresti, Eloisa Franchi, Elia Fraolini, Federica Furfaro, Paola Galimberti, A. Galtieri, Maria Gardini, Francesca Gavazzi, Elena Generali, Caterina Giannitto, Massimo Giovanni Giorgino, Benedetta Goletti, Elisabetta Guarino, Jacopo Guerrini, Giacomo Maria Guidelli, Flavia Jacobs, Hayato Kurihara, Michele Lagioia, Andrea Lania, Ezio Lanza, Elisabetta Lavezzi, Luca Librè, Ana Lleò, Ferdinando Loiacono, Laura Loy, Giovanni Lughezzani, Romano Fabio Lutman, Marta Maccallini, Paola Magnoni, Alfonso Maiorino, Alberto Malesci, Riccardo Mantovani, Davide Marchettini, Arianna Marinello, Nikolaos Markopoulos, Enrico Marrano, Chiara Masetti, Gherardo Mazziotti, Angelo Milani, Marco Mirani, Paola Morelli, Francesca Motta, Federica Mrakic Sposta, Valeria Mundula, Irene Nasone, Mattia Nigro, Paolo Omodei, Monica Ormas, Arianna Pagliaro, Silvia Paiardi, Roberta Paliotti, Alessia Pavesi, Rosa Pedale, Vittorio Pedicini, Francesco Pegoraro, Gaia Pellegatta, Marta Pellegrino, Alessandra Pestalozza, Gennaro Petriello, Sara Piccini, Giorgio Pivato, Daria Pocaterra, Laura Poliani, Dario Poretti, Paoletta Preatoni, Fabio Procopio, M. Profili, Francesca Puggioni, Luca Pugliese, Nicola Pugliese, Francesca Racca, Michele Randazzo, Damiano Regazzoli, Francesco Reggiani, Marta Ripoll Pons, Stefano Rodolfi, Giulia Ronzoni, Lidia Ruongo, Clara Sacco, Michele Sagasta, Maria Teresa Sandri, Giuseppe Sarra, Marzia Savi, Iside Scarfò, Dana Shiffer, Federico Sicoli, Simone Solano, Virginia Solitano, Anna Stainer, Matteo Stella, G. Strangio, Antonio Taormina, Francesca Ilaria Teofilo, Lucia Testoni, Federica Tordato, C. Torrisi, Angela Trabucco, Luisa Ulian, Rossella Valentino, Chiara Valeriano, Walter Vena, Simona Verlingieri, Edoardo Vespa, Antonio Voza, Antonio Voza, Valentina Zanuso, Alessandra Zilli, Aurora Zumbo,

Long-Term Effects of COVID-19

To evaluate the post- coronavirus disease-19 (COVID-19) outcome of thyroid function in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyrotoxicosis. This was a single-center prospective study involving 29 patients (11 females, 18 males; median age 64 years, range: 43–85) with thyrotoxicosis diagnosed after hospitalization for COVID-19 and then followed-up for a median period of 90 days (range: 30–120) after hospital discharge. At follow-up, patients were evaluated for serum thyrotropin (TSH), free-thyroxine (FT4), free-triiodiothyronine (FT3), TSH receptor antibodies (TRAb), thyroglobulin antibodies (TgAb), thyroperoxidase antibodies (TPOAb) and ultrasonographic thyroid structure. After recovery of COVID-19, serum TSH values significantly increased (P < 0.001) and FT4 values significantly decreased (P = 0.001), without significant change in serum FT3 (P = 0.572). At follow-up, 28 subjects (96.6%) became euthyroid whereas overt hypothyroidism developed in one case. At the ultrasound evaluation of thyroid gland, hypoecogenicity was found in 10 patients (34.5%) and in these cases serum TSH values tended to be higher than those without thyroid hypoecogenity (P = 0.066). All subjects resulted to be negative for TgAb, TPOAb and TRAb. In a short-term follow-up, thyroid function spontaneously normalized in most subjects with SARS-CoV-2-related thyrotoxicosis. However, thyroid hypoecogenicity was found in a remarkable number of them and future longer-term studies are needed to clarify whether this ultrasonographic alteration may predispose to develop late-onset thyroid dysfunction.