Produção Nacional
Three SARS-CoV-2 reinfection cases by the new Variant of Concern (VOC) P.1/501Y.V3
2021; Research Square (United States); Linguagem: Inglês
10.21203/rs.3.rs-318392/v1
AutoresFelipe Gomes Naveca, Cristiano Fernandes da Costa, Valdinete Alves do Nascimento, Victor Costa de Souza, André de Lima Guerra Corado, Fernanda Nascimento, Ágatha Costa, Débora Duarte, George Silva, Matilde Mejía, Karina Pessoa, Luciana Gonçalves, Maria Júlia Brandão, Michele Silva de Jesus, Marineide Silva, Tirza Mattos, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Rubens Costa Filho, Tsuyoshi Sekizuka, Kentaro Itokawa, Masanori Hashino, Makoto Kuroda, Marilda Mendonça Siqueira, Gabriel Luz Wallau, Edson Delatorre, Tiago Gräf, Gonzalo Bello, Paola Cristina Resende,
Tópico(s)Bacillus and Francisella bacterial research
ResumoAbstract The SARS-CoV-2 lineage B.1.1.28 has been evolving in Brazil since February 2020 giving origin to multiple local clades including the new Variant of Concern (VOC) designated P.1 or 501Y.V3. The recent emergence of sub-lineages with convergent mutations in the spike (S) protein raises concern about the potential impact on viral infectivity and immune escape. We describe here the first three confirmed SARS-CoV-2 reinfections cases with the new VOC P.1 in residents of the Amazonas state, Brazil. Three female patients, 29, 40, and 50-year-old, were RT-PCR confirmed for SARS-CoV-2 on two occasions, with at least 92 days apart. Next-generation sequencing and phylogenetic analysis were conducted to precisely access the SARS-CoV-2 lineages of each infection event. SARS-CoV-2 genomic analysis confirmed three cases of reinfections caused by the VOC P.1 in patients that were primo-infected by distinct viral lineages 3–9 months earlier. Case 1 (29-year-old) was positive on March 24, 2020 (lineage B.1.195) and then on December 30, 2020 (lineage P.1); case 2 (50-year-old) was positive on October 19, 2020 (lineage B.1.1.33) and on January 19, 2021 (lineage P.1); case 3 (40-year-old) was positive on April 22, 2020 (lineage B.1.195) and on January 29, 2021 (lineage P.1). The three patients displayed low mean Ct values (< 22) at nasopharyngeal samples and reported less severe illness during reinfection. The present study provides the first evidence of the new VOC P.1 causing multiple reinfections during the second epidemic peak in the Amazonas state. Our findings suggest that reinfected individuals may have been infectious. Although immune responses induced by natural infections do not necessarily prevent subsequent infections by the VOC P.1, they may still protect from severe disease.
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