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Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Molecular epidemiology of Mycobacterium tuberculosis in Brazil before the whole genome sequencing era: a literature review

2021; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 116; Linguagem: Inglês

10.1590/0074-02760200517

ISSN

1678-8060

Autores

Emilyn Costa Conceição, Richard Steiner Salvato, Karen Machado Gomes, Arthur Emil dos Santos Guimarães, Marília Lima da Conceição, Ricardo José de Paula Souza e Guimarães, Abhinav Sharma, Ismari Perini Furlaneto, Regina Bones Barcellos, Valdes Roberto Bóllela, Lívia Maria Pala Anselmo, María Carolina Sisco, Cristina Viana-Niero, Lucilaine Ferrazoli, Guislaine Refrégier, Maria Cristina da Silva Lourenço, Harrison Magdinier Gomes, Artemir Coelho de Brito, Marcos Catanho, Rafael Silva Duarte, Philip Noël Suffys, Karla Valéria Batista Lima,

Tópico(s)

Diagnosis and treatment of tuberculosis

Resumo

Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate for mycobacterial interspersed repetitive units - variable tandem repeats (MIRU-VNTR) of 1,613 isolates were: 73%, 33% and 28% based on 12, 15 and 24-loci, respectively; while for RFLP-IS6110 were: 84% among prison population in Rio de Janeiro, 69% among multidrug-resistant isolates in Rio Grande do Sul, and 56.2% in general population in São Paulo. These findings could improve tuberculosis (TB) surveillance and set up a solid basis to build a database of Mycobacterium genomes.

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