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Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

2021; Oxford University Press; Volume: 224; Issue: 9 Linguagem: Inglês

10.1093/infdis/jiab151

1537-6613

Jeanne Goupil de Bouillé, Corinne Vigouroux, Lorraine Plessis, Mathilde Ghislain, Jean‐Paul Teglas, Faroudy Boufassa, Cécile Goujard, Dorothée Vignes, Olivier Bouchaud, Dominique Salmon‐Céron, Laurence Meyer, Sophie Abgrall, O B., F B., Robert Carlier, Rosemary Dray‐Spira, Maria G. Roubelakis, Maria Grazia Cattaneo, Peng Lai, Lucie Marchand, Maciej Łałowski, Ventzislava Petrov–Sanchez, Peng Lai, Christine Rouzioux, Rémonie Seng, Rodolphe Thiébaut, Jean‐Paul Viard, Małgorzata Anna Słowińska, F B., Abdellatif Essabbani, Tatiana Feitoza, Maria Grazia Cattaneo, Alain-Serge Keita, Rémonie Seng, Tao Jia, Laurent Tran, Soraya Fellahi, Jean‐Philippe Bastard, Anne Simon, D. Beniken, Pierre Marie Girard, Zineb Ouazene, Bénédicte Lefebvre, Julie Lamarque, Adam Ameur, Gilles Pialoux, Julie Chas, Laurence Slama, F Z Makhoukhi, P Passe-Courtin, Laurence Gérard, Jean‐Michel Molina, Caroline Lascoux‐Combe, José Antonio González-Posada Delgado, S Parlier, Jean‐François Bergmann, V. Delcey, Pierre‐Olivier Sellier, A. Rami, Maguy Parrinello, O B., Lassina Traoré, A Benmammar, Mustafa Ali Kassim Kassim, Yazdan Yazdanpanah, Sophie Matheron, Sylvie Lariven, Véronique Joly, Charlie Rioux, F Louni, J. Zelie, Bolognani Fantin, Agnès Villemant, C. Bazin, Lauren A. Weiss, J. Pavie, Maria Adina Manea, G H Tarnier-Cochin, Dr. Sultana S, M.P. Pietri, J.-P. Viard, Aurélie Maignan, Marie Josée Dulucq, François Boué, Małgorzata Anna Słowińska, Imad Kansau, Dixit P.V., Steven Poirier, Maria Grazia Cattaneo, Olivier Lambotte, Katia Bourdic, Jean‐Daniel Lelièvre, C. Chesnel, Claudine Duvivier, O. Lortholary, F. Touam, Diego Rey, Peter Fischer, M L Batard and, M. Mohseni Zadeh, A Richard, Thomas Gille, Marie‐Laure Paillère Martinot, Anne Pachard, David B. Neau, Séverine Le Puil, Philippe Morlat, S. Caldato, Louis Bernard, Marie Charlotte Hallouin-Bernard, O Bourgault, C Chirouze, M.C. Thiebaut-Drobacheff, Alexis Proust, Quentin Gardiennet, Jacques Reynes, Clara Diago Crisol, C Tramoni, T. May, M P Bouillon, M Delestan, M. André, Agnès Meybeck, Meaghan Marien, Julie Moreau, Marie-Josèphe Carmantrand, Line Meddeb, M. Martinot, Michel Guignard, Carle Blanco Bétancourt, Anna Ivanova, F. Raffi, L Larmetand, H. Hue, Philippe Van de Perre, Armelle Pegeot, Laurent Cotte, Carole Wehbe Chidiac, Stanislas Ogoudjobi, Djamila Makhloufi, Sandra Gibert, André Cabie, Sylvie Abel, Patrick Hochedez, François Ronin, Ana Batalla, C Cerland, S. Pierre-François, B. Rozé,

HIV Research and Treatment

We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART).Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5-24.9 [ calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, <50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25-29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models.After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21-23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese.Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.