Voltar
Revisão Produção Nacional Revisado por pares
BIBTEX RIS

Genetic variations in the human immune system influence susceptibility to tegumentary leishmaniasis: a systematic review and meta-analysis

2021; Taylor & Francis; Volume: 17; Issue: 5 Linguagem: Inglês

10.1080/1744666x.2021.1906650

ISSN

1744-8409

Autores

Daniele Stéfanie Sara Lopes Lera‐Nonose, Larissa Ferreira de Oliveira, Aline Ávila Brustolin, Thais Silva Santos, Jully Oyama, Áquila Carolina Fernandes Herculano Ramos‐Milaré, Mariana de Souza Terron Monich, Izabel Galhardo Demarchi, Quirino Alves de Lima Neto, Jorge Juarez Vieira Teixeira, Maria Valdrinez Campana Lonardoni,

Tópico(s)

Research on Leishmaniasis Studies

Resumo

Objectives The outcomes of tegumentary leishmaniasis (TL) rely on a complex interaction between the host immune system and the parasite. This study assessed the influence of polymorphisms in immune-related genes on TL.Methods Web of Science, Scopus, PubMed, and Embase databases were searched systemically. The meta-analysis used a retrospective model in examining alleles, heterozygotes, and homozygotes. A quality assessment and an analysis of cumulative evidence were performed.Results A total of 29 genes (encoding for cytokines, chemokines, and other immune receptors) and 84 polymorphisms were analyzed. The IL-1β_rs16944 (OR = 1.341, p = 0.003), TNF-α_rs1800629 (OR = 3.804, p = 0.004), MIF_rs755622 (OR = 3.357, p = 0.001), and INF- γ_rs243056 (OR = 1.670, p = 0.028) polymorphisms were speculated as risk factor for TL. They decrease the expression of the corresponding genes crucial for TL control. The quality assessment score was approximately 50%, suggesting the need for a clear method and polymorphism characterization for further comparison. The relevant risk of bias and other considerations resulted in low and moderate cumulative evidence confidence.Conclusions IL-1β_rs16944, TNF-α_rs1800629, MIF_rs755622, and INF-γ_rs2430561 polymorphisms were speculated as risk factor for TL, corroborating that IL-1β, TNF-α, INF-γ, and MIF are involved in the TL pathogenesis.

Referência(s)