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Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41598-021-85788-0

2045-2322

José C. Páez-Franco, Jiram Torres-Ruíz, Víctor A. Sosa‐Hernández, Rodrigo Cervantes‐Díaz, Sandra Romero‐Ramírez, Alfredo Pérez‐Fragoso, David Eduardo Meza-Sánchez, Juan Manuel Germán-Acacio, José Luis Maravillas‐Montero, Nancy R. Mejía‐Domínguez, Alfredo Ponce‐de‐León, Alfredo Ulloa‐Aguirre, Diana Gómez‐Martín, Luis Llorente,

Adipose Tissue and Metabolism

Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.