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Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients

2021; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2021.04.06.21254949

Mounzer Agha, Maggie Blake, Charles Chilleo, Alan Wells, Ghady Haidar,

COVID-19 Clinical Research Studies

Abstract Studies describing SARS-CoV-2 immune responses following mRNA vaccination in hematology malignancy (HM) patients are virtually non-existent. We measured SARS-CoV-2 IgG production in 67 HM patients who received 2 mRNA vaccine doses. We found that 46% of HM patients did not produce antibodies and were therefore vaccine non-responders. Patients with B-cell CLL were at a particularly high risk, as only 23% had detectable antibodies despite the fact that nearly 70% of these patients were not undergoing cancer therapy. HM patients should be counseled about the ongoing risk of COVID-19 despite vaccination. Routine measurement of post-vaccine antibodies in HM patients should be considered. Novel strategies are needed to prevent COVID-19 in these individuals.