Complete remission in plasma cell leukaemia
1986; Wiley; Volume: 62; Issue: 3 Linguagem: Inglês
10.1111/j.1365-2141.1986.tb02964.x
ISSN1365-2141
AutoresCarlomaurizio Montecucco, Alberto Riccardi, Giampaolo Merlini, Edoardo Ascari,
Tópico(s)Protein Degradation and Inhibitors
ResumoS ummary . Two patients with primary plasma cell leukaemia who achieved complete remission are reported. They were treated with induction therapy consisting of a multipeptide derivative of sarcolysin, Peptichemio, given intravenously, combined with vincristine and/or prednisone, followed by conventional melphalan‐prednisone therapy. 5–7 months following the beginning of therapy, both patients attained a complete remission which lasted 23 and 6 months; second remission was not achieved. Survival from starting therapy was 57 and 16 months respectively. These cases indicate that intravenous alkylating agents can induce a complete remission in plasma cell leukaemia similar to that achieved in other acute leukaemias.
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