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BIBTEX RIS

Avaliacao dos gangliosidos na regeneracao nervosa em ratos

2002; Brazilian Society of Orthopedics and Traumatology; Volume: 37; Linguagem: Português

ISSN

2255-4971

Autores

Antonio Augusto Nunes de Abreu, Tang H Wei, Arnaldo Valdir Zumiotti,

Tópico(s)

Signaling Pathways in Disease

Resumo

Effect of gangliosides on nerve regeneration in rats The authors studied the effect of the intraperitoneal administration of gangliosides (30mg/kg) for 30 days after sciatic crush injury in rats. The double-blind study evaluated nine rats which received gangliosides, and 11 rats which received tamponade solution for the same period. The sciatic function index was evaluated in the preoperative period, then in the first, fourth, and sixth week after nerve lesion. No significant difference was found between the groups. Nerve regeneration was histopathologically evaluated by the analysis of fiber density, neural tissue percentage, and average area of neural fiber, proximal and distal to the lesion, and compared to the normal limb. Furthermore, no significant difference was found between groups. The administration of gangliosides does not interfere in the quality of nerve regeneration. RESUMO Os autores avaliaram o efeito dos gangliosidios administrados intraperitonealmente na dose de 30mg/kg, por 30 dias, apos esmagamento do nervo ciatico em ratos. O estudo foi do tipo duplo-cego: nove ratos receberam gangliosidio e 11, solucao tamponada pelo mesmo periodo. Avaliou-se o indice de funcao do ciatico no preoperatorio, primeira, quarta e sexta semanas de posoperatorio, nao se encontrando diferenca significativa entre os grupos. Avaliou-se a regeneracao nervosa histomorfometricamente atraves da densidade de fibras, percentagem de tecido neural e area media de uma fibra das porcoes proximais e distais a lesao e do lado normal. Nao houve diferencas entre os grupos. A administracao dos gangliosidios nao interferiu na qualidade da regeneracao nervosa. Unitermos – Gangliosidios; nervo; uso terapeutico; regeneracao; trauma

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