Produção Nacional
Revisado por pares
Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America
2021; Springer Science+Business Media; Linguagem: Inglês
10.1007/s00431-021-04052-9
ISSN1432-1076
AutoresRicardo Pignatelli, Clara Vázquez Antona, Iván Romero Rivera, Patricia Alvarez Zenteno, Yanet Toribio Acosta, Manuel Huertas-Quiñones, Carlos Álvarez Murillo, Franklin Mendoza Torres, Carlos Fernández Cabalín, Ana Camacho, Alex Alcántara Pérez, Ana Braga Lombardi, Andressa Mussi Soares, Carolina Torres Garcia, Cibelle Teixeira da Siva Borges, Claudia Villalba, Cristhian Ramírez Lechado, Deborah Trevisan Dias, Diana Aravena Morales, Elizabeth Mora Copete, Guillermo Larios Goldenberg, Jahaira Sussety Salazar, Jessica Alchundia Moreira, Junko Asakura, Karla Solórzano Sabando, Klébia Magalhães Pereira Castello Branco, Lida Toro Rosas, Magna Pereira Duarte, María G. Jiménez-Carbajal, Martha Rubio Hernandez, Moisés Mier-Martínez, Nancy Garay Echeverría, Olga Maza Caneva, Patricia Romero Sepulveda, Paulina Agurto Díaz, Ruth Rugel Plúas, Theo Contreras Alvarado, Lorena Tapia Faundes, Yeny Briones Diaz, Justin P. Zachariah,
Tópico(s)Mechanical Circulatory Support Devices
ResumoLatin America (LATAM) children offer special insight into Severe Acute Respiratory Syndrome Coronavirus 2 (SARS COV2) due to high-risk race/ethnicity, variability in medical resources, diverse socioeconomic background, and numerous involved organ systems. This multinational study of LATAM youth examined the distinguishing features of acute or late multisystem SARS COV2 with versus without cardiac involvement. A consecutive sample of youth 0–18 years old (N = 98;50% male) presenting with multisystem SARS COV2 to 32 centers in 10 Latin American countries participating in a pediatric cardiac multi-imaging society were grouped as with versus without cardiac involvement, defined as abnormal echocardiographic findings or arrhythmia. Collected clinical data were analyzed by Student's t-test or Fisher's exact test. Cardiac (N = 48, 50% male) versus no cardiac (N = 50, 50% male) were similar in age; weight; nonrespiratory symptoms; and medical history. The cardiac group had 1 death and symptoms including coronary artery dilation, ejection fraction <50%, pericardial effusion, peripheral edema, arrhythmia, and pulmonary artery thrombus. The cardiac group had higher risk of ICU admission (77% vs 54%, p = 0.02); invasive ventilation (23% vs 4%,p = 0.007); vasoactive infusions (27% vs 4%, p = 0.002); prominent respiratory symptoms (60% vs 36%, p < 0.03); abnormal chest imaging (69% vs 34%, p = 0.001); troponin (33% vs 12%, p = 0.01); alanine aminotransferase (33% vs 12%, p = 0.02); and thrombocytopenia (46% vs 22%, p = 0.02). Receiver operating curve analysis showed that abnormal laboratories had 94% sensitivity and 98% negative predictive value on the need for ICU interventions. Conclusion: In LATAM children with multisystem SARS COV2, cardiac involvement was prevalent. Cardiac involvement was more likely to require ICU interventions, certain abnormal labs, and respiratory involvement.
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