Bioinspired Conductive Silk Microfiber Integrated Bioelectronic for Diagnosis and Wound Healing in Diabetes
2021; Wiley; Volume: 31; Issue: 19 Linguagem: Inglês
10.1002/adfm.202010461
ISSN1616-3028
AutoresZhanrong Jia, Jinglei Gong, Yan Zeng, Jinhui Ran, Jin Liu, Kefeng Wang, Chaoming Xie, Xiong Lu, Jun Wang,
Tópico(s)Electrospun Nanofibers in Biomedical Applications
ResumoAbstract Ideal epidermal bioelectronics can be used not only for long‐term detection of physiological signals for disease diagnosis but also for chronic disease treatment. Silk, an animal‐derived fiber with good biocompatibility and skin‐affinity, is widely used in flexible bioelectronics. However, silk fibers are insulating. In this study, ultralong conductive silk microfibers (mSFs) are fabricated by extracting mSF from raw silk using a bioinspired extraction‐protection process with the assistance of polydopamine, followed by deposition of poly(3,4‐ethylenedioxythiophene) (PEDOT) on its surface. The conductive mSFs are produced and used to fabricate a conductive flexible silk fibroin patch, which is used as a conformable bioelectronic for monitoring physiological signals. In addition, as the conductive mSF possessed anti‐oxidative activity, the patch exhibits excellent performance in chronic diabetic wound healing by reducing inflammation and regulating oxidative stress. Thus, this bioinspired strategy produces conductive silk fibers that can be used as biocompatible building blocks, opening new avenues for employing passive silk as an active component in the design of epidermal wound repair biomaterials and next‐generation flexible epidermal bioelectronics.
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