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COVID-19 vaccine challenges: What have we learned so far and what remains to be done?

2021; Elsevier BV; Volume: 125; Issue: 5 Linguagem: Inglês

10.1016/j.healthpol.2021.03.013

1872-6054

Rebecca Forman, Soleil Shah, Patrick Jeurissen, Mark Jit, Elías Mossialos,

Viral Infections and Outbreaks Research

Developing and distributing a safe and effective SARS-CoV-2 (COVID-19) vaccine has garnered immense global interest. Less than a year after COVID-19 was declared a pandemic, several vaccine candidates had received emergency use authorization across a range of countries. Despite this scientific breakthrough, the journey from vaccine discovery to global herd immunity against COVID-19 continues to present significant policy challenges that require a collaborative, global response. We offer a framework for understanding remaining and new policy challenges for successful global vaccine campaigns against COVID-19 as well as potential solutions to address them. Decision-makers must be aware of these challenges and strategize solutions that can be implemented at scale. These include challenges around maintaining R&D incentives, running clinical trials, authorizations, post-market surveillance, manufacturing and supply, global dissemination, allocation, uptake, and clinical system adaption. Alongside these challenges, financial and ethical concerns must also be addressed.