Portal de Periódicos da CAPES

Low HDL and high triglycerides predict COVID-19 severity

2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41598-021-86747-5

2045-2322

L. Masana, Eudald Correig, Daiana Ibarretxe, Eva Anoro, Juan Antonio Arroyo, Carlos Rilova Jericó, Carolina Guerrero, Marcel·la Miret, Sílvia Näf, Anna Pardo, Verónica Perea, Rosa Pérez-Bernalte, Núria Plana, Rafael Ramírez-Montesinos, Meritxell Royuela, Cristina Soler, María Urquizu-Padilla, Alberto Zamora, Juan Pedro‐Botet, Cèlia Rodríguez-Borjabad, Natàlia Andreychuk, Ana Irene Malo, Laia Matas, Maria del Señor Cortes-Fernandez, Marta Mauri, Rosa M. Borrallo, Àngels Pedragosa, Pilar Gil-Lluís, Ana Lacal-Martínez, Patricia Barragan-Galló, Glòria Vives-Masdeu, Carmen Arto-Fernández, Omar El Boutrouki, Andrea Vázquez-Escobales, Maria Cristina Antón-Alonso, Sergio Rivero-Santana, A Michavila Gómez, Sara L. Garcia, Núria Rial-Lorenzo, Lourdes Ruiz‐Ortega, Oriol Alonso-Gisbert, Ana Inés Méndez-Martínez, Hada Iglesias-López, Elisenda Climent, Robert Güerri‐Fernández, Jade Soldado, Marta Fanlo‐Maresma, Alicia Taboada, Liliana Gutiérrez-Carrasquilla,

Liver Disease Diagnosis and Treatment

Abstract Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.