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Synergistic Activity of Diclofenac Sodium with Oxacillin Against Planktonic Cells and Biofilm of Methicillin-Resistant Staphylococcus Aureus Strains

2021; Future Medicine; Volume: 16; Issue: 6 Linguagem: Inglês

10.2217/fmb-2020-0095

1746-0921

Helaine Almeida Queiroz, Cecília Rocha da Silva, João Batista de Andrade Neto, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Letícia Serpa Sampaio Moreno, Fátima DD Barroso, Lisandra J da Silva, Thiago M Cândido, Leilson C de Oliveira, Jacó RL de Mesquita, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,

Antimicrobial agents and applications

Aim: To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm. Materials & methods: Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry. Results: The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant Staphylococcus aureus strains. Conclusion: This combination caused damage to the integrity of the membrane and ruptures in the DNA of the cells, leading to apoptosis.