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Outcomes of COVID-19 patients intubated after failure of non-invasive ventilation: a multicenter observational study

2021; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41598-021-96762-1

2045-2322

Annalisa Boscolo, Laura Pasin, Nicolò Sella, Chiara Pretto, Martina Tocco, Enrico Tamburini, Paolo Rosi, Enrico Polati, Katia Donadello, Leonardo Gottin, Andrea Vianello, Giovanni Landoni, Paolo Navalesi, Ilaria Valeri, Giulio Andreatta, Leonardo Gandolfi, Alessandra Gadaldi, Nicolò Brumana, Edoardo Forin, Christelle Correale, Davide Fregolent, Pier Francesco Pirelli, Davide Marchesin, Matteo Perona, Nicola Franchetti, Michele Della Paolera, Caterina Simoni, Tatiana Falcioni, Alessandra Tresin, Chiara Schiavolin, Aldo Schiavi, Sonila Vathi, Daria Sartori, Alice Sorgato, Elisa Pistollato, Federico Linassi, Gian Lorenzo Golino, Laura Frigo, Eugenio Serra, Demetrio Pittarello, Ivo Tiberio, Ottavia Bond, Elisa Michieletto, Luisa Muraro, Arianna Peralta, Paolo Persona, Enrico Petranzan, Francesco Zarantonello, Tommaso Pettenuzzo, Alessandro Di Graziano, Alessandro De Cassai, L. Bernardi, Roberto Pianon, Flavio Badii, Enrico Bosco, Moreno Agostini, Paride Trevisiol, Antonio Farnia, Mario Peta, Lorella Altafini, Mauro Antonio Calò, Marco Meggiolaro, Francesco Lazzari, Ivan Martinello, Giorgio Fullin, Francesco Papaccio, Fabio Toffoletto, Alfeo Bonato, Camilla Sgarabotto, Fabio Baratto, Francesco Montacciani, Parnigotto Alessandra, G. Gagliardi, Gioconda Ferraro, Luigi Ongaro, Marco Baiocchi, Vinicio Danzi, Silvia De Rosa, Enrico Polati, Katia Donadello, Leonardo Gottin, Paolo Zanatta, Ezio Sinigaglia, Alessandra Da Ros, Simonetta Marchiotto, Silvia Bassanini, Massimo Zamperini, Ivan Daroui, Walter Mosaner, Rosalba Lembo,

Family and Patient Care in Intensive Care Units

Abstract The efficacy of non-invasive ventilation (NIV) in acute respiratory failure secondary to SARS-CoV-2 infection remains controversial. Current literature mainly examined efficacy, safety and potential predictors of NIV failure provided out of the intensive care unit (ICU). On the contrary, the outcomes of ICU patients, intubated after NIV failure, remain to be explored. The aims of the present study are: (1) investigating in-hospital mortality in coronavirus disease 2019 (COVID-19) ICU patients receiving endotracheal intubation after NIV failure and (2) assessing whether the length of NIV application affects patient survival. This observational multicenter study included all consecutive COVID-19 adult patients, admitted into the twenty-five ICUs of the COVID-19 VENETO ICU network (February–April 2020), who underwent endotracheal intubation after NIV failure. Among the 704 patients admitted to ICU during the study period, 280 (40%) presented the inclusion criteria and were enrolled. The median age was 69 [60–76] years; 219 patients (78%) were male. In-hospital mortality was 43%. Only the length of NIV application before ICU admission (OR 2.03 (95% CI 1.06–4.98), p = 0.03) and age (OR 1.18 (95% CI 1.04–1.33), p < 0.01) were identified as independent risk factors of in-hospital mortality; whilst the length of NIV after ICU admission did not affect patient outcome. In-hospital mortality of ICU patients intubated after NIV failure was 43%. Days on NIV before ICU admission and age were assessed to be potential risk factors of greater in-hospital mortality.