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Single-cell multi-omics analysis of the immune response in COVID-19

2021; Nature Portfolio; Volume: 27; Issue: 5 Linguagem: Inglês

10.1038/s41591-021-01329-2

1546-170X

Emily Stephenson, Gary Reynolds, Rachel A. Botting, Fernando J. Calero‐Nieto, Michael D. Morgan, Zewen Kelvin Tuong, Karsten Bach, Waradon Sungnak, Kaylee B. Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, Katarzyna Kania, Justin Engelbert, Bayanne Olabi, Jarmila Stremenova Spegarova, Nicola K. Wilson, Nicole Mende, Laura Jardine, Louis Gardner, Issac Goh, Dave Horsfall, Jim McGrath, Simone Webb, Michael Mather, Rik G.H. Lindeboom, Emma Dann, Ni Huang, Krzysztof Polański, Elena Prigmore, Florian Gothe, Jonathan Scott, Rebecca P. Payne, Kenneth F. Baker, Aidan T. Hanrath, Ina Schim van der Loeff, Andrew Barr, Amada Sanchez-Gonzalez, Laura Bergamaschi, Federica Mescia, Josephine L. Barnes, Eliz Kilich, Angus de Wilton, Anita Saigal, Aarash Saleh, Sam M. Janes, Claire M. Smith, Nusayhah Hudaa Gopee, Caroline Wilson, Paul Coupland, Jonathan Coxhead, Vladimir Yu Kiselev, Stijn van Dongen, Jaume Bacardit, Hamish W. King, Anthony Rostron, A. John Simpson, Sophie Hambleton, Elisa Laurenti, Paul Lyons, Kerstin B. Meyer, Marko Nikolić, C.J. Duncan, Kenneth G. C. Smith, Sarah A. Teichmann, Menna R. Clatworthy, John C. Marioni, Berthold Göttgens, Muzlifah Haniffa,

COVID-19 Clinical Research Studies

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16