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Perinatal outcomes of pregnancies resulting from assisted reproduction technology in SARS-CoV-2-infected women: a prospective observational study

2021; Elsevier BV; Volume: 116; Issue: 3 Linguagem: Inglês

10.1016/j.fertnstert.2021.04.005

1556-5653

Virginia Engels Calvo, Sara Cruz Melguizo, Alejandra Abascal-Saiz, Laura Forcén Acebal, Amalia Sánchez-Migallón, Pilar Pintado Recarte, Celia Cuenca Marín, Beatriz Marcos Puig, Pablo G. Del Barrio Fernández, Olga Nieto Velasco, María Luisa de la Cruz, Óscar Martínez Pérez, María Belén Garrido Luque, Camino Fernández, Ana Villalba Yarza, Esther María Canedo Carballeira, María Begoña Dueñas Carazo, Rosario Redondo Aguilar, Ángeles Sánchez-Vegazo García, E. Álvarez-Silvares, María Isabel Pardo Pumar, Macarena Alférez Álvarez-Mallo, Víctor Muñoz Carmona, Noelia Pérez Pérez, Cristina Álvarez Colomo, Onofre Alomar Mateu, Claudio Marañon Di Leo, María del Carmen Parada Millán, Adrián Martín García, José Navarrina Martínez, Anna Mundó Fornell, Elena Pascual Salvador, Tania Manrique Gómez, Marta Ruth Meca Casbas, Noemí Freixas Grimalt, Adriana Aquise, M. M. Gil, Eduardo Cazorla, Alberto Armijo Sánchez, María Isabel Conca Rodero, Ana Belén Oreja Cuesta, Cristina Ruiz Aguilar, Susana Fernández García, Mercedes Ramírez Gómez, Esther Vanessa Aguilar Galán, Rocío López Pérez, Carmen Baena Luque, Luz María Jiménez Losa, Susana Soldevilla Pérez, María Reyes Granell Escobar, Manuel Domí­nguez, Flora Navarro Blaya, Juan Carlos Wizner de Alva, Rosa Pedró Carulla, Encarnación Carmona Sánchez, Judit Canet Rodríguez, Eva Morán Antolín, Montse Macià, Laia Pratcorona, Irene Gastaca Abásolo, Begoña Martínez Borde, Óscar Vaquerizo Ruiz, J Ruiz Aragón, Raquel González Seoane, María Teulón González, Lourdes González, Cristina Lesmes Heredia, José Román Broullón, María Joaquina Gimeno Gimeno, Alma María Posadas San Juan, Otilia González Vanegas, Ana M. Fernández‐Alonso, Lucía Díaz Meca, Alberto Puerta Prieto, María del Pilar Guadix Martín, Carmen Lago, José Antonio Sainz‐Bueno, Mónica Catalina Coello, María José Núñez Valera, Lucas Cerrillos González, José Adanez García, Elena Perez, Marta Roqueta-Vall-llosera, María Begoña Encinas Pardilla, Marta García Sánchez, Laura González Rodríguez, Pilar Pintado Recarte, Elena Pintado Paredes, Paola Carmona Payán, Yosu Franco Iriarte, Luís San Frutos Llorente,

Pregnancy and preeclampsia studies

To evaluate the perinatal and maternal outcomes of pregnancies in women infected with SARS-CoV-2, comparing spontaneous and in vitro fertilization (IVF) pregnancies (with either own or donor oocytes).Multicenter, prospective, observational study.78 centers participating in the Spanish COVID19 Registry.1,347 pregnant women with SARS-CoV-2 positive results registered consecutively between February 26 and November 5, 2020.The patients' information was collected from their medical records, and multivariable regression analyses were performed, controlling for maternal age and the clinical presentation of the infection.Obstetrics and neonatal outcomes, pregnancy comorbidities, intensive care unit admission, mechanical ventilation need, and medical conditions.The IVF group included 74 (5.5%) women whereas the spontaneous pregnancy group included 1,275 (94.5%) women. The operative delivery rate was high in all patients, especially in the IVF group, where cesarean section became the most frequent method of delivery (55.4%, compared with 26.1% of the spontaneous pregnancy group). The reason for cesarean section was induction failure in 56.1% of the IVF patients. IVF women had more gestational hypertensive disorders (16.2% vs. 4.5% among spontaneous pregnancy women, adjusted odds ratio [aOR] 5.31, 95% confidence interval [CI] 2.45-10.93) irrespective of oocyte origin. The higher rate of intensive care unit admittance observed in the IVF group (8.1% vs. 2.4% in the spontaneous pregnancy group) was attributed to preeclampsia (aOR 11.82, 95% CI 5.25-25.87), not to the type of conception.A high rate of operative delivery was observed in pregnant women infected with SARS-CoV-2, especially in those with IVF pregnancies; method of conception did not affect fetal or maternal outcomes, except for preeclampsia.NCT04558996.