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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin

2021; Taylor & Francis; Volume: 8; Issue: 3 Linguagem: Inglês

10.1080/23723556.2021.1910474

2372-3556

Belén Gómez‐González, Gaetana Sessa, Aura Carreira, Andrés Aguilera,

BRCA gene mutations in cancer

In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T207A missense variant found in breast cancer patients.