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Anti-carbamylated protein antibodies positivity and disease activity in Hispanic patients with established rheumatoid arthritis: An observational study

2021; Oxford University Press; Volume: 32; Issue: 2 Linguagem: Inglês

10.1080/14397595.2021.1913277

1439-7609

David Vega‐Morales, Mario Alberto Garza‐Elizondo, Leendert A. Trouw, Karina I Gonzalez‐Torres, Ernesto Torres-López, Miryam Eguia-Bernal, Salvador Azahel Loredo-Alanis, Tayde Sarahí Gracia‐Aréchiga, Brenda Roxana Vázquez-Fuentes, Diana Daniela Castañeda-Martínez, M. M. Castañeda-Martínez, Cesar Elizondo-Solís, Andrés Mendiola‐Jiménez, Mario C. Salinas‐Carmona, Pablo Herrera-Sandate, Jesús Alberto Cárdenas‐de la Garza, Gerardo E Rodriguez-Sanchez, D. Á. Galarza-Delgado,

Monoclonal and Polyclonal Antibodies Research

We aimed to determine the prevalence of anti-carbamylated protein (anti-CarP) antibodies in Mexican Hispanics with established rheumatoid arthritis (RA) and to assess their relationship with disease activity.A cohort study was conducted in 278 patients with established RA during an 18-month follow-up. We measured IgG/IgM/IgA rheumatoid factor (RF), IgG anticitrullinated protein antibodies (ACPA) and IgG/IgM/IgA anti-CarP antibodies using enzyme-linked immunosorbent assay (ELISA). For disease activity, we performed the 28-joint disease activity score with erythrocyte sedimentation rate (DAS28-ESR). Repeated measures one-way ANOVA was used to test the association between anti-CarP IgG antibody status and longitudinal DAS28-ESR scores. Patients were evaluated at baseline and at 6, 12, and 18 months during follow-up.Anti-CarP IgG antibodies were positive in 47.8% of patients and, accounting for all isotypes, in 9.5% of patients with negative RF and ACPA. Triple antibody positivity was present in 42.6% of patients in our sample. Anti-CarP IgG antibody positivity did not show statistically significant differences in mean DAS28-ESR when compared to anti-CarP IgG antibody negative patients at baseline, 6, 12 or 18 months.Anti-CarP IgG antibodies are not associated to a higher disease activity in Hispanic patients with established RA. Our findings suggest that the clinical value of measuring anti-CarP antibodies in RA diminishes over time.