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Contribution of Matrix Metalloproteinase-1 Genotypes to Colorectal Cancer in Taiwan

2021; Volume: 18; Issue: 3 Linguagem: Inglês

10.21873/cgp.20255

1790-6245

Ming‐Hsien Wu, Te‐Cheng Yueh, Wen-Shin Chang, Chia-Wen Tsai, Chun‐Kai Fu, Mei‐Due Yang, CHIEN-CHIH YU, DA-TIAN BAU,

Lipoproteins and Cardiovascular Health

Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate the contribution of Matrix metalloproteinase-1 genotypes to CRC risk in Taiwan.A total of 362 cases and 362 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined. The environmental factors and clinical-pathological records were also analyzed.The genotypic frequency of MMP-1 rs1799750 were different between the CRC and control groups (p for trend=0.0083). 1G/2G and 1G/1G were associated with lower risk (p=0.0438 and 0.0030, adjusted OR=0.73 and 0.54, 95%CI=0.54-0.90 and 0.37-0.83). Among non-smokers, those with 1G/2G and 1G/1G genotypes were at 0.70- and 0.48-fold odds of having CRC. Among non-alcohol drinkers, people with 1G/2G and 1G/1G genotypes were at 0.71- and 0.54-fold odds. The 1G/1G genotype were statistically lower among CRC patients with lymph node metastasis (7.2%) than those without (19.0%).The genotypes at MMP-1 rs1799705 play a role in determining susceptibility to CRC risk in Taiwan.