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Epigenome-wide association study of COVID-19 severity with respiratory failure

2021; Elsevier BV; Volume: 66; Linguagem: Inglês

10.1016/j.ebiom.2021.103339

2352-3964

Manuel Castro de Moura, Verónica Dávalos, Laura Planas‐Serra, Damiana Álvarez‐Errico, Carles Arribas, Montserrat Ruíz, Sergio Aguilera, Jesús Troya, Juan Valencia-Ramos, Valentina Vélez-Santamaría, Agustí Rodríguez‐Palmero, Judit Villar-García, Juan Pablo Horcajada, Sergiu Albu, Carlos Casasnovas, Anna Rull, Laia Reverté, Beatriz Dietl, David Dalmau, María J. Arranz, Laia Llucià‐Carol, Anna M. Planas, Jordi Pérez‐Tur, Israel Fernández‐Cadenas, Paula Villares, Jair Tenorio, Roger Colobrán, Andrea Martín-Nalda, Pere Soler‐Palacín, Francesc Vidal, Aurora Pujol, Manel Esteller,

COVID-19 and Mental Health

Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities.