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Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019

2021; Oxford University Press; Volume: 8; Issue: 8 Linguagem: Inglês

10.1093/ofid/ofab153

2328-8957

James Regan, James P. Flynn, Alexandra Rosenthal, Hannah Jordan, Yijia Li, Rida Chishti, Françoise Giguel, Heather Corry, Kendyll Coxen, Jesse Fajnzylber, Elizabeth Gillespie, Daniel R. Kuritzkes, Nir Hacohen, Marcia B. Goldberg, Michael R. Filbin, Xu G. Yu, Lindsey R. Baden, Ruy M. Ribeiro, Alan S. Perelson, Jessica M. Conway, Jonathan Z. Li, Betelihem A. Abayneh, Patrick Allen, Galit Alter, Diane Antille, Katrina Armstrong, Alejandro B. Balazs, Julia Bals, Max Barbash, Yannic C. Bartsch, Julie Boucau, Siobhan Boyce, Joan Braley, Kelley R. Branch, Katherine Broderick, Julia Carney, Andrew Chan, Josh Chevalier, Fatema Z. Chowdhury, George Q. Daley, Susan Davidson, Michael Dougan, David Drew, Kevin Einkauf, Ashley Elliman, Jon Fallon, Liz Fedirko, Kelsey Finn, Keith T. Flaherty, Jeanne Flannery, Pamela J. Forde, Pilar García‐Broncano, Elise Gettings, David Golan, Amanda Griffin, Sheila Grimmel, Kathleen Grinke, Kathryn Hall, Ciputra Adijaya Hartana, Meg Healy, Howard M. Heller, Deborah Henault, Grace Holland, Chenyang Jiang, Nikolaus Jilg, Paulina Kapłonek, Marshall Karpell, Chantal Kayitesi, Evan C. Lam, Vlasta LaValle, Kristina Lefteri, Xiaodong Lian, Mathias Lichterfeld, Daniel Lingwood, Hang Liu, Jin-Qing Liu, Yiting Lu, Sarah Luthern, Natasha Ly, Jordan Marchewka, Britanni Martino, Roseann McNamara, Ashlin R. Michell, Ilan Millstrom, Noah Miranda, Christian Nambu, Susan C. Nelson, Marjorie Noone, Claire O’Callaghan, Christine Ommerborn, Mathew Osborn, Lois Chris Pacheco, Nicole Phan, Shiv Pillai, Falisha A. Porto, Yelizaveta Rassadkina, Alexandra Reissis, Alex Rosenthal, Francis F. Ruzicka, Edward T. Ryan, Kyra Seiger, Kathleen Selleck, Libera Sessa, Arlene Sharpe, Christianne Sharr, Sally Shin, Nishant K. Singh, Sue Slaughenhaupt, Kimberly Smith Sheppard, Weiwei Sun, Xiaoming Sun, Elizabeth Suschana, Hannah Ticheli, Alicja Trocha-Piechocka, Vivine Wilson, Colline Wong, Daniel Worrall, Alex Zhu, Z Hill, Edward Demers, Kelly Judge, Bruce D. Walker, Peggy S. Lai, Jonathan Z. Li, Musie Ghebremichael,

COVID-19 epidemiological studies

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.